1981 Football Championship of Ukrainian SSR was the 51st season of association football competition of the Ukrainian SSR, which was part of the Soviet Second League in Zone 5. The season started on 4 April 1981.
The 1981 Football Championship of Ukrainian SSR was won by Kryvbas Kryvyi Rih. Qualified for the interzonal playoffs, the team from Dnipropetrovsk Oblast did not manage to gain promotion by placing second in its group.
Note: in 1970, Football Championship of Ukrainian SSR included competitions in both Soviet Class A Second Group (upper level) and Soviet Class B (lower level). Next year 1971, Class B was disbanded, while Class A Second Group was changed to the Soviet Second League.