The 1966 Kansas Jayhawks football team represented the University of Kansas in the Big Eight Conference during the 1966 NCAA University Division football season. In their ninth and final season under head coach Jack Mitchell, the Jayhawks compiled a 2–7–1 record (0–6–1 against conference opponents), tied for last place in the Big Eight Conference, and were outscored by opponents by a combined total of 188 to 106.^[1][2] They played their home games at Memorial Stadium in Lawrence, Kansas.

The team's statistical leaders included Donnie Shanklin with 732 rushing yards, Halley Kampschroeder with 278 receiving yards and Bob Skahan with 299 passing yards.^[3] Jerry Barnett and Bill Wohlford were the team captains.^[2]

Date	Opponent	Site	Result	Attendance	Source
September 17	Texas Tech*	Memorial Stadium Lawrence, KS	L 7–23	28,165
September 24	at Arizona*	Arizona Stadium Tucson, AZ	W 35–13	33,147	[4]
October 1	at Minnesota*	Memorial Stadium Minneapolis, MN	W 16–14	43,147–43,579
October 8	at Iowa State	Clyde Williams Field Ames, IA	L 7–24	23,015–23,105
October 15	Oklahoma	Memorial Stadium Lawrence, KS	L 0–35	37,252
October 22	at Oklahoma State	Lewis Field Stillwater, OK	L 7–10	22,148
October 29	at Kansas State	Memorial Stadium Manhattan, KS (rivalry)	T 3–3	17,985
November 5	No. 6 Nebraska	Memorial Stadium Lawrence, KS (rivalry)	L 13–24	40,881
November 12	Colorado	Memorial Stadium Lawrence, KS	L 18–35	36,158
November 19	at Missouri	Memorial Stadium Columbia, MO (Border War)	L 0–7	52,279
*Non-conference game Homecoming Rankings from AP Poll released prior to the game