The year 1669 in music involved some significant events.

• February 17 – Première of Alessandro Melani's opera L'empio punito at the Teatro di Palazzo Colonna in Rome. The work was commissioned by Marie Mancini.

• Luigi Battiferri – Ricercari, Op.3
• Giovanni Maria Bononcini – Op. 3, a collection of sonatas in canon
• Henri Dumont – Cinq messes en plain-chant
• Johann Caspar Kerll – Delectus sacrarum cantionum, 26 motets for 2–5 voices, 2 violins and basso continuo
• Henry Lawes
  • Select Ayres and Dialogues
  • The Treasury of Musick
• Samuel Capricornus
  • Continuatio theatri musici
  • Scelta musicale
  • Theatrum musicum
• Giovanni Antonio Pandolfi – Sonate cioè balletti, sarabande, correnti, passacagli, capricetti e una trombetta...
• Maurizio Cazzati – Varii, e diversi capricci per camera, Op. 50

• Johann Schmelzer – Sonata a 4, La Carolietta

• Francesco Cavalli – Coriolano
• Antonio Cesti – Genserico
• Antonio Draghi – Achille in Sciro
• Jean-Baptiste Lully – Monsieur de Pourceaugnac, LWV 41

• April 6 – Johann Christopf Faber, composer, organist, and organ builder (died 1742)
• February 2 – Louis Marchand, organist, harpsichordist and composer (died 1732)
• August 24 – Alessandro Marcello, composer (died 1747)
• October 10 – Johann Nicolaus Bach, composer (died 1753)
• October 13 – Charles Desmazures, composer (died 1736)
• date unknown
  • Johann Samuel Beyer, composer (died 1744)
  • Miquel López Sebastián, composer (died 1723)

• April 6 – Lars Wivallius, librettist (born 1605)
• April 17 – Antonio Bertali, violinist and composer (born 1605)
• May? – Étienne Richard, composer, organist and harpsichordist (born c.1621)
• October 14 – Antonio Cesti, opera composer (born 1623)
• October 28 – Agustin Moreto y Cavana, poet (born 1618)
• date unknown
  • Richard Ayleward, musician and composer (born 1626)
  • Christopher Simpson, viola da gamba player and composer (born c.1605)
• probable – Étienne Moulinié, composer (born c.1600)