Events from the year 1646 in art.

• (unknown)

• Georges de La Tour - The Smoker
• Claude Lorrain
  • The Judgement of Paris (c.1645-46)
  • Landscape with Hagar and the Angel
• Carlo Dolci - Saint Andrew Praying Before his Crucifixion
• Gerrit Dou - Girl Chopping Onions
• Guercino
  • Annunciation
  • The Circumcision
  • Saul Attacking David
• Murillo - The Angels' Kitchen
• Jacob van Ruisdael - Wooded Dunes
• Kano Sansetsu - Old Plum
• Karel Škréta - The Crucifixion (St. Nicholas Church, Prague)
• Philips Wouwerman - Cavalry making a Sortie from a Fort on a Hill

• January 6 - Jan Van Cleef, Flemish painter (died 1716)
• February 10 - Hans Adam Weissenkircher, Austrian Baroque court painter (died 1695)
• April 20 - Giacinto Calandrucci, Italian painter at the studio of Carlo Maratta (died 1707)
• August 8 - Godfrey Kneller, portrait painter in England (died 1723)
• date unknown
  • Andrea Belvedere, Italian painter (died unknown)
  • Lorenzo Bergonzoni, Italian painter (died 1700)
  • Juan Correa, Mexican painter of primarily religious themes (died 1716)
  • Pietro Dandini, Italian painter active in Florence (died 1712)
  • Benoît Farjat, French engraver (died 1724)
  • José García Hidalgo, Spanish Baroque painter (died 1719)
  • Francesco Monti, Italian painter of battle scenes (died 1712)
  • Pietro Paolo Raggi, Italian Caravaggisti painter of Bacchanal and landscape subjects (died 1724)
• probable - Jean-Baptiste Corneille, French painter, etcher, and engraver (died 1695)

• April 10 - Santino Solari, Swiss architect and sculptor (born 1576)
• August 19 - Francesco Furini, Italian Baroque painter from Florence (born 1600/1603)
• October 28 (bur.) - William Dobson, English portrait painter (born 1611)
• date unknown
  • Alessandro Albini, Italian painter of the early Baroque period (born 1568)
  • Antonio Bisquert, Spanish painter of the Baroque period (born 1596)
  • Huang Daozhou, Chinese calligrapher, scholar and official of the Ming Dynasty (born 1585)
  • Daniel Dumonstier, French portraitist in crayon (born 1574)
  • Isaack Gilsemans, Dutch merchant and artist (born 1606)
  • Ludovico Lana, Italian painter, mainly active in Modena (born 1597)
  • Niccolo Laniere, Italian painter and engraver (born 1608)
• probable - Giovanni Stefano Marucelli, Italian painter and architect active mainly in Tuscany (born 1586)