فأر تشاكراجاتي

فأر تشاكراجاتي (Chakragati mouse) (ويعرف اختصارًا باسم ckr)هو طافرة فأر تبدلي غزري يظهر سلوكًا وحركة مفرطة النشاط. وهو أيضًا مختل في تثبيط قبل النبض والتثبيط الكامن[1] ولديه بعض أشكال الشذوذ في الدماغ مثل ضخامة البُطَين الوَحْشِيّ[2] المطابقة لنماذج النمط الظاهري الداخلي لـلفصام وهو ما يجعلها مفيدة في مراقبة دواء مضادات الذهان.[3] وقد حاز هذا الفأر حاليًا على ترخيص من شركة تشاكرا بايوتك (Chakra Biotech).

المراجع

  1. ^ Verma V, Tan CH, Ong WY؛ وآخرون (مارس 2008). "The chakragati mouse shows deficits in prepulse inhibition of acoustic startle and latent inhibition". Neurosci. Res. ج. 60 ع. 3: 281–8. DOI:10.1016/j.neures.2007.11.007. PMID:18164085. مؤرشف من الأصل في 2019-12-09. {{استشهاد بدورية محكمة}}: Explicit use of et al. in: |مؤلف= (مساعدة)صيانة الاستشهاد: أسماء متعددة: قائمة المؤلفين (link)
  2. ^ Torres G, Meeder BA, Hallas BH؛ وآخرون (2005). "Ventricular size mapping in a transgenic model of schizophrenia". Developmental Brain Research. ج. 154 ع. 1: 35–44. DOI:10.1016/j.devbrainres.2004.08.011. PMID:15617753. {{استشهاد بدورية محكمة}}: Explicit use of et al. in: |مؤلف= (مساعدة)صيانة الاستشهاد: أسماء متعددة: قائمة المؤلفين (link)
  3. ^ Dawe GS, Ratty AK (2007). "The chakragati mouse: A mouse model for rapid in vivo screening of antipsychotic drug candidates". Biotechnology Journal. ج. 2 ع. 11: 1344–52. DOI:10.1002/biot.200700145. PMID:17886239.

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