لوموستين

لوموستين
لوموستين
لوموستين
الاسم النظامي
N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea
يعالج
ورم حميد رئوي  [لغات أخرى]‏،  وساركوما لمفية  [لغات أخرى]‏،  وسرطان الكلية،  وورم ميلانيني،  ولمفوما هودجكين مختلطة الخلوية  [لغات أخرى]‏،  وسرطان الدماغ  [لغات أخرى]‏،  وسرطان الدماغ  [لغات أخرى][1]،  ولمفوما هودجكين[1]  تعديل قيمة خاصية (P2175) في ويكي بيانات
اعتبارات علاجية
اسم تجاري Gleostine
مرادفات 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
ASHP
Drugs.com
أفرودة
مدلاين بلس a682207
فئة السلامة أثناء الحمل D (أستراليا) D (الولايات المتحدة)
طرق إعطاء الدواء Oral (محفظة (دواء))
بيانات دوائية
توافر حيوي ~100%
ربط بروتيني 50%
استقلاب (أيض) الدواء كبد
عمر النصف الحيوي 16–48 hours (metabolites)
معرّفات
CAS 13010-47-4 ☑Y
ك ع ت L01L01AD02 AD02
بوب كيم CID 3950
IUPHAR 7214
ECHA InfoCard ID 100.032.585  تعديل قيمة خاصية (P2566) في ويكي بيانات
درغ بنك DB01206
كيم سبايدر 3813 ☑Y
المكون الفريد 7BRF0Z81KG ☑Y
كيوتو D00363 ☑Y
ChEBI CHEBI:6520 ☒N
ChEMBL CHEMBL514 
ترادف 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
بيانات كيميائية
الصيغة الكيميائية C9H16ClN3O2 
بيانات فيزيائية
نقطة الانصهار 90 °C (194 °F)

لوموستين ويتم تسويقه الآن باسم Gleostine هو مركب نتروزويوريا مؤلكل يستخدم في العلاج الكيميائي. يرتبط ارتباطًا وثيقًا بالسمستين وهو في نفس عائلة الستربتوزوتوسين. وهو دواء قابل للذوبان في الدهون بدرجة عالية،[3] وبالتالي فهو يعبر حاجز للدم في الدماغ. وهذه الخاصية تجعله مثالياً لعلاج أورام الدماغ، وهذا هو الاستخدام الأساسي له، على الرغم من أنه يستخدم أيضًا لعلاج لمفوما هودجكين كخيار من الخط الثاني.[4]

مراجع

  1. ^ Inxight: Drugs Database، QID:Q57664317
  2. ^ Lee FY، Workman P، Roberts JT، Bleehen NM (1985). "Clinical pharmacokinetics of oral CCNU (lomustine)". Cancer Chemotherapy and Pharmacology. ج. 14 ع. 2: 125–31. DOI:10.1007/bf00434350. PMID:3971475.
  3. ^ "BC Cancer Agency Cancer Drug Manual. Lomustine (CCNU; CeeNU)" (PDF). مؤرشف من الأصل (PDF) في 2019-08-17. اطلع عليه بتاريخ 2016-07-15.
  4. ^ "PRODUCT INFORMATION CeeNU®(lomustine)". TGA eBusiness Services. Bristol-Myers Squibb Australia Pty Ltd. 30 سبتمبر 2015. مؤرشف من الأصل (PDF) في 2020-05-05. اطلع عليه بتاريخ 2018-04-23.


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