| 羟甲基戊二酸单酰辅酶A还原酶 (NADPH)
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| 羟甲基戊二酸单酰辅酶A还原酶晶体结构（PDB 1dq8）[1]
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| 命名
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| 系统命名
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(R)-mevalonate:NADP+ oxidoreductase (CoA-acylating)
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| 缩写
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| 别名
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hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate); 3-hydroxy-3-methylglutaryl-CoA reductase; β-hydroxy-β-methylglutaryl coenzyme A reductase; hydroxymethylglutaryl CoA reductase (NADPH); S-3-hydroxy-3-methylglutaryl-CoA reductase; NADPH-hydroxymethylglutaryl-CoA reductase; HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA); 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); hydroxymethylglutaryl-CoA reductase (NADPH2)
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| 识别码
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| EC編號
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1.1.1.34
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| CAS号
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9028-35-7
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| 数据库
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| IntEnz
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IntEnz浏览
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| BRENDA
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BRENDA入口
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| ExPASy
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NiceZyme浏览
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| KEGG
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KEGG入口
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| MetaCyc
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代谢路径
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| PRIAM
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概述
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| PDB
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RCSB PDB PDBj PDBe PDBsum
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| 基因本体
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AmiGO / EGO
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羟甲基戊二酸单酰辅酶A还原酶 (NADPH)（英語：hydroxymethylglutaryl-CoA reductase (NADPH)，EC 1.1.1.34 （页面存档备份，存于互联网档案馆））是一种以NAD+或NADP+为受体、作用于供体CH-OH基团上的氧化还原酶。这种酶能催化以下酶促反应：
- (R)-甲羟戊酸 + CoA + 2 NADP+
(S)-3-羟基-3-甲基戊二酰辅酶A + 2 NADPH + 2 H+
羟甲基戊二酸单酰辅酶A还原酶 (NADPH)主要参与诸如胆固醇等类固醇的合成。用于降低胆固醇的他汀类药物通过抑制这种酶来发挥作用。
参考文献
