"The Ballroom Waltz" - 克利夫·艾德爾曼（英语：Cliff Eidelman） (Song that plays when Sander Cohen descends the steps after the player has completed his masterpiece)
"And All the While I'm Loving You" -Essentials Jazz Masters (Background tune in "New Year's Eve Alone" audio diary)
《生化奇兵2》的原創配樂由加里·席曼作曲。它是以名稱「來自燈塔的聲音」（Sounds From The Lighthouse (Official BioShock 2 Score)）於2010年2月9日放在遊戲特別版內的CD上發售。本配樂共有來自遊戲中的26條曲目。
Sounds From The Lighthouse
曲序
曲目
时长
1.
"Pairbond - BioShock 2 Theme"
2:33
2.
"Waking Up in 1959 (Multiplayer Main Menu)"
1:31
3.
"Ten Years Later"
1:46
4.
"Protecting His Charge"
1:07
5.
"Welcome Back"
2:20
6.
"Cult of Lamb"
1:18
7.
"Out the Airlock"
1:42
8.
"How She Sees the World"
2:46
9.
"Grace Under the Ocean"
1:51
10.
"The Abyss"
1:24
11.
"Big Sister on the Move"
2:00
12.
"Send Him Howling Back to Hell"
2:07
13.
"Eleanor's Darkness"
1:42
14.
"That Symbol on Your Hand"
2:00
15.
"Drained Memories"
2:40
16.
"Entrance to Eden"
1:38
17.
"Persephone"
1:07
18.
"Cell Block"
1:14
19.
"Lockdown March"
1:29
20.
"Welcome to the Drop (Alt. with Vocal)"
1:38
21.
"Under the Tracks (Unused with Vocal)"
2:44
22.
"Research"
1:11
23.
"Destroying the Lobby"
1:10
24.
"Gil's Entertainment"
1:49
25.
"Escape"
3:32
26.
"Eleanor's Lullaby"
1:39
已授權的原聲帶
在《生化奇兵2》中已授權的音樂以Amazon MP3和CD專輯形式在2010年4月15日正式發行，標題為「生化奇兵2：官方原聲帶（特別版）」（Bioshock 2: The Official Soundtrack - Music From And Inspired By The Game (Special Edition)）。包含18首曲目，全長52分鐘。[4]
官方原聲帶
"The Boogie Man - Todd Rollins & His Orchestra with Chick Bullock" - 3:03
(How Much Is) That Doggie in the Window? - 帕蒂·佩奇 - 2:38
Twentieth Century Blues - 諾爾·克華德 - 3:34
Nightmare - 亞提·蕭 及 His New Music - 2:49
Daddy, Won't You Please Come Home? - Annette Hanshaw - 2:58
Praise the Lord and Pass the Ammunition - Kay Kyser & His Orchestra - 2:32
Dawn of a New Day - Horace Heidt & His Musical Knights - 2:30
Night and Day - 比莉·荷莉戴 及 Her Orchestra - 2:58
My Heart Belongs to Daddy - Eddy Duchin & His Orchestra, featuring Mary Martin - 2:54
"Will the Circle Be Unbroken (choral version)"（Ada Ruth Habershon, Charles Hutchinson Gabriel）
Maureen Murphy
2:56
4.
"Lighter Than Air"
1:46
5.
"Lutece"
2:45
6.
"The Battle for Columbia I"（Garry Schyman, Jim Bonney）
1:16
7.
"The Girl in the Tower"
0:37
8.
"Elizabeth"
2:02
9.
"The Songbird"
1:55
10.
"Rory O'More/Saddle the Pony"（Samuel Lover/anon）
Elvie Miller, Rodney Miller, David Porter
3:41
11.
"The Battle for Columbia II"
2:01
12.
"The Readiness is All"（Ken Levine, Jim Bonney）
1:32
13.
"Lions Walk With Lions"
1:06
14.
"Will the Circle Be Unbroken"（Ada Ruth Habershon, Charles Hutchinson Gabriel）
Troy Baker, Courtnee Draper
0:40
15.
"Unintended Consequences"
1:00
16.
"The Battle for Columbia III"
0:59
17.
"Family Reunion"
1:08
18.
"Solace"（Scott Joplin）
Duncan Watt
3:40
19.
"The Battle for Columbia IV"
1:19
20.
"The Battle for Columbia V"
1:08
21.
"Let Go"
0:32
22.
"Doors"
1:19
23.
"The Girl for the Debt"
1:10
24.
"Back in the Boat"
1:07
25.
"AD"
1:21
26.
"Smothered"
1:13
27.
"Baptism"（Garry Schyman, Jim Bonney）
1:25
28.
"Will the Circle Be Unbroken (full version)"（Ada Ruth Habershon, Charles Hutchinson Gabriel）
Troy Baker, Courtnee Draper
4:43
已授權的原聲帶
一些加入在《生化奇兵：無限之城》中的音樂以MP3專輯，和隨選服務專輯於2013年2月1日非正式發行，標題為「被揭露的原創歌曲」（The Original Songs Uncovered (Tracks Inspired By Bioshock Infinite)）。包含12首曲目，全長33:49分鐘。[8]
