四硝酸二氯六氨二(1,6-己二胺)合三铂![]() |
|
| ATC碼 | |
|---|
|
| CAS号 | 172903-00-3  Y |
|---|
| UNII | |
|---|
| ChEBI | |
|---|
|
| 化学式 | C12H50Cl2N14O12Pt3 |
|---|
| 摩尔质量 | 1,238.77 g·mol−1 |
|---|
| 3D模型（JSmol） | |
|---|
[O-][N+]([O-])=O.[O-][N+]([O-])=O.Cl[Pt-2]([NH3+])([NH3+])[NH2+]CCCCCC[NH2+][Pt-2]([NH3+])([NH3+])[NH2+]CCCCCC[NH2+][Pt-2]([NH3+])([NH3+])Cl.[O-][N+]([O-])=O.[O-][N+]([O-])=O
|
四硝酸二氯六氨二(1,6-己二胺)合三铂是一种配位化合物，化学式为[ClPt(NH3)2]2μ-{trans-Pt(NH3)2[H2N(CH2)6NH2]2}(NO3)4，有专利报道了它的合成。[1]它具有抗癌活性，在对三种卵巢瘤和四种黑色素瘤的研究中发现它的IC50比顺铂至少低20倍。[2]
参考文献
- ^ Valsecchi, Mariella; Conti, Marco; Del Greco, Luisa; Bugatti, Carlo; Menta, Ernesto; Giuliani, Ferdinando C.; Manzotti, Carla; Spinelli, Silvano; Farrell, Nicholas. Trinuclear cationic platinum complexes having antitumor activity and pharmaceutical compositions containing them. 1995. WO9526968.
- ^ Carla Manzotti; Graziella Pratesi; Ernesto Menta; Roberto Di Domenico; Ennio Cavalletti; Heinz H. Fiebig; Lloyd R. Kelland; Nicholas Farrell; Donatella Polizzi; Rosanna Supino; Gabriella Pezzoni; Franco Zunino. BBR 3464: A Novel Triplatinum Complex, Exhibiting a Preclinical Profile of Antitumor Efficacy Different from Cisplatin. Clin Cancer Res (2000) 6 (7): 2626–2634.
延伸阅读
- Michael E. Oehlsen; Yun Qu; Nicholas Farrell. Reaction of Polynuclear Platinum Antitumor Compounds with Reduced Glutathione Studied by Multinuclear (1H, 1H−15N Gradient Heteronuclear Single-Quantum Coherence, and 195Pt) NMR Spectroscopy. Inorg. Chem. 2003, 42, 18, 5498–5506. doi:10.1021/ic030045b.
