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SNU-5

SNU-5Seoul National University-5)是一種次四倍體人類胃癌細胞系,最初在1987年分離自一名33歲亞洲女性低分化胃癌患者的轉移性腹水,而該患者先前接受過5-氟尿嘧啶阿黴素絲裂黴素-C等化學治療。SNU-5細胞的模態染色體數為87-88,而在大部分細胞中發現18條或以上的標記染色體英语Marker chromosome。正常的N1不存在,而N5、N7、N10、N19和N20在大多數具有四個副本。至少檢測到一條正常的X染色體,但是沒有檢測到正常的Y染色體。SNU-5細胞對VIP受體及芳香族L-氨基酸脫羧酶陽性反應,但是對胃泌素受體陰性反應,並且表達表面糖蛋白癌胚抗原TAG-72英语Tumor-associated glycoprotein 72[1]

研究用途

SNU-5細胞在无胸腺裸鼠中經常用作腹膜腔轉移(Peritoneal dissemination)模型,因為它具有很高的腹膜腔轉移潛力[2]。同時亦曾有研究利用SNU-5細胞,發現冬凌草甲素(Oridonin)在抑制c-Met英语C-Met磷酸化和c-Met依賴性細胞增殖方面具有較強的抑制作用,並且下調包括磷酸化c-Raf英语c-Raf、磷酸化Erk英语Extracellular signal-regulated kinases和磷酸化Akt的下游信號分子的表達[3]。此外,冬凌草甲素在SNU-5皮下異種移植模型中,透過細胞減量方式,具有明顯的抗腫瘤活性,而它抗腫瘤活性的功效是呈劑量依賴性的,並且顯示出對c-Met磷酸化的強烈抑制作用[3]。這些實驗結果表明,冬凌草甲素通過直接調控c-Met信號通路,在體內體外對SNU-5細胞發揮抗腫瘤作用,其抗腫瘤作用主要是基於其抗增殖和抗血管生成作用[3]

參考資料

  1. ^ Park, JG; Frucht, H; LaRocca, RV; Bliss DP, Jr; Kurita, Y; Chen, TR; Henslee, JG; Trepel, JB; Jensen, RT; Johnson, BE. Characteristics of cell lines established from human gastric carcinoma.. Cancer research. 1990-05-01, 50 (9): 2773–80 [2020-02-15]. PMID 2158397. (原始内容存档于2020-02-15). 
  2. ^ Sakakura, C; Hagiwara, A; Nakanishi, M; Shimomura, K; Takagi, T; Yasuoka, R; Fujita, Y; Abe, T; Ichikawa, Y; Takahashi, S; Ishikawa, T; Nishizuka, I; Morita, T; Shimada, H; Okazaki, Y; Hayashizaki, Y; Yamagishi, H. Differential gene expression profiles of gastric cancer cells established from primary tumour and malignant ascites.. British journal of cancer. 2002-11-04, 87 (10): 1153–61 [2020-02-15]. PMID 12402156. doi:10.1038/sj.bjc.6600580. (原始内容存档于2020-02-15). 
  3. ^ 3.0 3.1 3.2 Liu, H; Qian, C; Shen, Z. Anti-tumor activity of oridonin on SNU-5 subcutaneous xenograft model via regulation of c-Met pathway.. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2014-09, 35 (9): 9139–46 [2020-02-15]. PMID 24916572. doi:10.1007/s13277-014-2178-4. (原始内容存档于2020-02-15). 

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