SIN3A

SIN3转录调节同源物A（酵母）
SIN3 transcription regulator homolog A (yeast)
PDB rendering based on 1g1e.
有效结构
PDB 直系同源检索：PDBe, RCSB
标识
代号 SIN3A; DKFZp434K2235; FLJ90319; KIAA0700
扩展标识 遗传学：607776 鼠基因：107157 同源基因：32124 GeneCards: SIN3A Gene
直系同源体
物种 人类 小鼠
Entrez 25942 20466
Ensembl ENSG00000169375 ENSMUSG00000042557
UniProt Q96ST3 Q60520
mRNA序列 NM_001145357 NM_001110350
蛋白序列 NP_001138829 NP_001103820
基因位置 Chr 15:
75.66 – 75.75 Mb		 Chr 9:
57.07 – 57.13 Mb
PubMed查询 [1] [2]

成对两亲性螺旋蛋白SIN3A（英語：Paired amphipathic helix protein Sin3a）是一个由人类基因SIN3A编码的蛋白质[1][2]。

功能

SIN3A是一种转录调控蛋白，包含有成对两亲性螺旋结构域（paired amphipathic helix，PAH），对蛋白质互作非常重要[3]。

互作

SIN3A与下列蛋白有相互作用：

另见

参考文献

  1. ^ Yu F, Thiesen J, Stratling WH. Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2. Nucleic Acids Res. June 2000, 28 (10): 2201–6. PMC 105362 可免费查阅. PMID 10773092. doi:10.1093/nar/28.10.2201. 
  2. ^ Halleck MS, Pownall S, Harder KW, Duncan AM, Jirik FR, Schlegel RA. A widely distributed putative mammalian transcriptional regulator containing multiple paired amphipathic helices, with similarity to yeast SIN3. Genomics. August 1995, 26 (2): 403–6. PMID 7601471. doi:10.1016/0888-7543(95)80229-F. 
  3. ^ Entrez Gene: SIN3A SIN3 homolog A, transcription regulator (yeast). 
  4. ^ Youn HD, Liu JO. Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2. Immunity. 2000, 13 (1): 85–94. PMID 10933397. doi:10.1016/S1074-7613(00)00010-8. 
  5. ^ 5.0 5.1 Swanson KA, Knoepfler PS, Huang K, Kang RS, Cowley SM, Laherty CD, Eisenman RN, Radhakrishnan I. HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations. Nat. Struct. Mol. Biol. 2004, 11 (8): 738–46. PMID 15235594. doi:10.1038/nsmb798. 
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  8. ^ 8.0 8.1 8.2 8.3 8.4 Fleischer TC, Yun UJ, Ayer DE. Identification and characterization of three new components of the mSin3A corepressor complex. Mol. Cell. Biol. 2003, 23 (10): 3456–67. PMC 164750 可免费查阅. PMID 12724404. doi:10.1128/MCB.23.10.3456-3467.2003. 
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  23. ^ Laherty CD, Yang WM, Sun JM, Davie JR, Seto E, Eisenman RN. Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression. Cell. 1997, 89 (3): 349–56. PMID 9150134. doi:10.1016/S0092-8674(00)80215-9. 
  24. ^ Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML. Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Mol. Cell. Biol. 2004, 24 (13): 5639–49. PMC 480881 可免费查阅. PMID 15199122. doi:10.1128/MCB.24.13.5639-5649.2004. 
  25. ^ Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W. Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. Genes Dev. 2003, 17 (7): 896–911. PMC 196026 可免费查阅. PMID 12670868. doi:10.1101/gad.252103. 
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  31. ^ Brubaker K, Cowley SM, Huang K, Loo L, Yochum GS, Ayer DE, Eisenman RN, Radhakrishnan I. Solution structure of the interacting domains of the Mad-Sin3 complex: implications for recruitment of a chromatin-modifying complex. Cell. 2000, 103 (4): 655–65. PMID 11106735. doi:10.1016/S0092-8674(00)00168-9. 
  32. ^ Ayer DE, Lawrence QA, Eisenman RN. Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. Cell. 1995, 80 (5): 767–76. PMID 7889570. doi:10.1016/0092-8674(95)90355-0. 
  33. ^ Boeke J, Ammerpohl O, Kegel S, Moehren U, Renkawitz R. The minimal repression domain of MBD2b overlaps with the methyl-CpG-binding domain and binds directly to Sin3A. J. Biol. Chem. 2000, 275 (45): 34963–7. PMID 10950960. doi:10.1074/jbc.M005929200. 
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  39. ^ 39.0 39.1 39.2 Zhang Y, Sun ZW, Iratni R, Erdjument-Bromage H, Tempst P, Hampsey M, Reinberg D. SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Mol. Cell. 1998, 1 (7): 1021–31. PMID 9651585. doi:10.1016/S1097-2765(00)80102-1. 
  40. ^ Laherty CD, Billin AN, Lavinsky RM, Yochum GS, Bush AC, Sun JM, Mullen TM, Davie JR, Rose DW, Glass CK, Rosenfeld MG, Ayer DE, Eisenman RN. SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors. Mol. Cell. 1998, 2 (1): 33–42. PMID 9702189. doi:10.1016/S1097-2765(00)80111-2. 
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  42. ^ Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA. Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex. Mol. Cell. Biol. 2002, 22 (8): 2743–50. PMC 133736 可免费查阅. PMID 11909966. doi:10.1128/MCB.22.8.2743-2750.2002. 
  43. ^ Huang S, Brandt SJ. mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor. Mol. Cell. Biol. 2000, 20 (6): 2248–59. PMC 110841 可免费查阅. PMID 10688671. doi:10.1128/MCB.20.6.2248-2259.2000. 
  44. ^ David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A. Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein. Oncogene. 1998, 16 (19): 2549–56. PMID 9627120. doi:10.1038/sj.onc.1202043. 
  45. ^ Ward JO, McConnell MJ, Carlile GW, Pandolfi PP, Licht JD, Freedman LP. The acute promyelocytic leukemia-associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D(3)-induced monocytic differentiation of U937 cells through a physical interaction with vitamin D(3) receptor. Blood. 2001, 98 (12): 3290–300. PMID 11719366. doi:10.1182/blood.V98.12.3290. 
  46. ^ Wong CW, Privalsky ML. Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6. J. Biol. Chem. 1998, 273 (42): 27695–702. PMID 9765306. doi:10.1074/jbc.273.42.27695. 

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外部链接


SIN3A引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。