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Histatin 3
组氨素3
Histatin 3; 组氨素3
标识
代号	HTN3; HIS2; HTN2; HTN5
扩展标识	遗传学：142702 同源基因：133553 GeneCards: HTN3 Gene
基因本体论描述
分子功能	· protein binding; · metal ion binding;
细胞成分	· extracellular region;
生物过程	· biomineral tissue development; · killing of cells of other organism; · defense response to bacterium; · defense response to fungus;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	3347
Ensembl	ENSG00000205649
UniProt	P15516
mRNA序列	NM_000200
蛋白序列	NP_000191
基因位置	Chr 4:; 70.89 – 70.9 Mb
PubMed查询	[1]
	查; 论; 编;

HTN3，是一能夠指導組氨素3合成的基因片段^[1]^[2]。

功能

HTN3基因表達的初級產物爲組氨素3。組氨素是一類存在於唾液中的富含組氨酸的蛋白質，控制其合成的基因位點除了HTN3之外，還有H1N1。組氨素3在合成完畢後，還可以通過蛋白水解轉化成其它的組氨素（比如組氨素4-6）。能控制組氨素3合成的等位基因爲HIS2^[3]。

等位基因	基因	蛋白質
HIS1	HTN1	組氨素 1
HIS2	HTN3	組氨素 3 → 組氨素 4-6

參考

^ Entrez Gene: HTN3 histatin 3. （原始内容存档于2019-10-17）.
^ Sabatini LM, Azen EA. Histatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 and HIS2). Biochem. Biophys. Res. Commun. April 1989, 160 (2): 495–502 [2015-03-14]. PMID 2719677. doi:10.1016/0006-291X(89)92460-1. （原始内容存档于2019-02-16）.
^ Oudhoff MJ, Bolscher JG, Nazmi K, Kalay H, van 't Hof W, Amerongen AV, Veerman EC. Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay. FASEB J. November 2008, 22 (11): 3805–12. PMID 18650243. doi:10.1096/fj.08-112003.

拓展閱讀

Troxler RF, Offner GD, Xu T; et al. Structural relationship between human salivary histatins.. J. Dent. Res. 1990, 69 (1): 2–6. PMID 2303595. doi:10.1177/00220345900690010101.
vanderSpek JC, Offner GD, Troxler RF, Oppenheim FG. Molecular cloning of human submandibular histatins.. Arch. Oral Biol. 1990, 35 (2): 137–43. PMID 2344289. doi:10.1016/0003-9969(90)90175-A.
Sugiyama K, Ogino T, Ogata K. Rapid purification and characterization of histatins (histidine-rich polypeptides) from human whole saliva.. Arch. Oral Biol. 1990, 35 (6): 415–9. PMID 2372245. doi:10.1016/0003-9969(90)90202-L.
Sabatini LM, Azen EA. Histatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 and HIS2).. Biochem. Biophys. Res. Commun. 1989, 160 (2): 495–502. PMID 2719677. doi:10.1016/0006-291X(89)92460-1.
vanderSpek JC, Wyandt HE, Skare JC; et al. Localization of the genes for histatins to human chromosome 4q13 and tissue distribution of the mRNAs.. Am. J. Hum. Genet. 1989, 45 (3): 381–7. PMC 1683406 . PMID 2773933.
Oppenheim FG, Xu T, McMillian FM; et al. Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans.. J. Biol. Chem. 1988, 263 (16): 7472–7. PMID 3286634.
Dickinson DP, Ridall AL, Levine MJ. Human submandibular gland statherin and basic histidine-rich peptide are encoded by highly abundant mRNA's derived from a common ancestral sequence.. Biochem. Biophys. Res. Commun. 1988, 149 (2): 784–90. PMID 3426601. doi:10.1016/0006-291X(87)90436-0.
Sabatini LM, Azen EA. Two coding change mutations in the HIS2(2) allele characterize the salivary histatin 3-2 protein variant.. Hum. Mutat. 1994, 4 (1): 12–9. PMID 7951254. doi:10.1002/humu.1380040103.
Sabatini LM, Ota T, Azen EA. Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family.. Mol. Biol. Evol. 1993, 10 (3): 497–511. PMID 8336540.
Tsai H, Raj PA, Bobek LA. Candidacidal activity of recombinant human salivary histatin-5 and variants.. Infect. Immun. 1997, 64 (12): 5000–7. PMC 174480 . PMID 8945538.
Iontcheva I, Oppenheim FG, Offner GD, Troxler RF. Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system.. J. Dent. Res. 2000, 79 (2): 732–9. PMID 10728974. doi:10.1177/00220345000790020601.
Naurato N, Wong P, Lu Y; et al. Interaction of tannin with human salivary histatins.. J. Agric. Food Chem. 2000, 47 (6): 2229–34. PMID 10794615. doi:10.1021/jf981044i.
Gusman H, Travis J, Helmerhorst EJ; et al. Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease.. Infect. Immun. 2001, 69 (3): 1402–8. PMC 98034 . PMID 11179305. doi:10.1128/IAI.69.3.1402-1408.2001.
Grogan J, McKnight CJ, Troxler RF, Oppenheim FG. Zinc and copper bind to unique sites of histatin 5.. FEBS Lett. 2001, 491 (1–2): 76–80. PMID 11226423. doi:10.1016/S0014-5793(01)02157-3.
Gyurko C, Lendenmann U, Helmerhorst EJ; et al. Killing of Candida albicans by histatin 5: cellular uptake and energy requirement. Antonie Van Leeuwenhoek. 2002, 79 (3–4): 297–309. PMID 11816973. doi:10.1023/A:1012070600340.
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Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Li XS, Reddy MS, Baev D, Edgerton M. Candida albicans Ssa1/2p is the cell envelope binding protein for human salivary histatin 5. J. Biol. Chem. 2003, 278 (31): 28553–61. PMID 12761219. doi:10.1074/jbc.M300680200.
Ahmad M, Piludu M, Oppenheim FG; et al. Immunocytochemical localization of histatins in human salivary glands. J. Histochem. Cytochem. 2004, 52 (3): 361–70. PMID 14966203. doi:10.1177/002215540405200307.
Castagnola M, Inzitari R, Rossetti DV; et al. A cascade of 24 histatins (histatin 3 fragments) in human saliva. Suggestions for a pre-secretory sequential cleavage pathway. J. Biol. Chem. 2004, 279 (40): 41436–43. PMID 15272024. doi:10.1074/jbc.M404322200.

[entrez-1] Entrez Gene: HTN3 histatin 3. （原始内容存档于2019-10-17）.

[pmid2719677-2] Sabatini LM, Azen EA. Histatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 and HIS2). Biochem. Biophys. Res. Commun. April 1989, 160 (2): 495–502 [2015-03-14]. PMID 2719677. doi:10.1016/0006-291X(89)92460-1. （原始内容存档于2019-02-16）.

[pmid18650243-3] Oudhoff MJ, Bolscher JG, Nazmi K, Kalay H, van 't Hof W, Amerongen AV, Veerman EC. Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay. FASEB J. November 2008, 22 (11): 3805–12. PMID 18650243. doi:10.1096/fj.08-112003.

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