组氨酸甲酯

组氨酸甲酯
别名 Methyl L-histidinate, HME
识别
CAS号 1499-46-3  checkY
7389-87-9（HCl）  ☒N
PubChem 92893
ChemSpider 83857
SMILES
 
  • COC(=O)[C@H](Cc1c[nH]cn1)N
Beilstein 957974
EINECS 216-109-3
ChEBI 70961
性质
化学式 C7H11N3O2
摩尔质量 169.18 g·mol−1
熔点 62-66 °C[1]
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

组氨酸甲酯（英語：Histidine methyl ester，缩写HME）是一种氨基酸酯，化学式为C7H11N3O2，可作为组氨酸脱羧酶的不可逆抑制剂[2][3][4]。它和苯甲醛反应，经氰基硼氢化钠还原， 可以得到N-苄基组氨酸甲酯[5]。

组氨酸甲酯与组氨酸脱羧酶结合

参考文献

  1. ^ Merrifield, R. B.; Woolley, D. W. The Synthesis of L-Seryl-L-histidyl-L-leucyl-L-valyl- L-glutamic Acid, a Peptide with Strepogenin Activity. Journal of the American Chemical Society. 1956-09, 78 (18): 4646–4649. doi:10.1021/ja01599a032. 
  2. ^ Lane, Roger S; Manning, James M; Snell, Esmond E. Histidine decarboxylase of lactobacillus 30a: inactivation and active-site labeling by L-histidine methyl ester. Biochemistry. 2002, 15 (19): 4180–5. PMID 963031. doi:10.1021/bi00664a008. 
  3. ^ Alston, Theodore A; Abeles, Robert H. Reaction of Lactobacillus histidine decarboxylase with L-histidine methyl ester. Biochemistry. 2002, 26 (13): 4082–5. PMID 3651438. doi:10.1021/bi00387a051. 
  4. ^ Komori, H; Nitta, Y; Ueno, H; Higuchi, Y. Structural Study Reveals That Ser-354 Determines Substrate Specificity on Human Histidine Decarboxylase. The Journal of Biological Chemistry. 2012, 287 (34): 29175–83. PMC 3436558 可免费查阅. PMID 22767596. doi:10.1074/jbc.M112.381897 可免费查阅. 
  5. ^ Roy, Moumita Singha; Meng, Xiaofeng; Koda, Karuna; Shrestha, Andrina; Putman, Joshua I; Gout, Delphine; Armstrong, Daniel W.; Lovely, Carl J. Total synthesis of haploscleridamine, villagorgin A and an approach towards lissoclin C. Organic & Biomolecular Chemistry. 2023, 21 (7): 1422–1434. doi:10.1039/D2OB01908F. 

Read other articles:

Bandar Udara Berlin Tegel

Berlin-Tegel beralih ke halaman ini. Untuk daerah di Reinickendorf, Berlin, lihat Tegel. Bandar Udara Internasional Berlin beralih ke halaman ini. Untuk bandara internasional lain di Berlin, lihat Bandar Udara Berlin Schönefeld. Bandar Udara Berlin TegelFlughafen Berlin-TegelIATA: TXLICAO: EDDTInformasiJenisPublikPengelolaFlughafen Berlin Brandenburg GmbHMelayaniBerlin, JermanLokasiReinickendorf, Berlin, JermanMaskapai utama easyJet Eurowings Ryanair Sundair Ketinggian dpl mdplKoor...

 

 

Bessarabia

Peta Bessarabia tahun 1927 Bessarabia (Basarabia di Rumania, Бесарабія di Ukraina, Бессарабия di Rusia, Бесарабия di Bulgaria, Besarabya di Turki, Bessarabien di Jerman, בעסאַראַביע dalam Yiddish) adalah istilah untuk entitas geografi di Eropa Timur berbatasan dengan Sungai Dniester di timur dan Sungai Prut di barat. Bessarabia adalah nama yang digunakan oleh Kekaisaran Rusia untuk bagian timur Moldavia yang dianeksasi dari Kesultanan Utsmaniyah sebagai ...

 

 

Diving at the 2013 World Aquatics Championships – Women's 3 metre springboard

Women's 3 metre springboard at the 2013 World Aquatics ChampionshipsDates26 July (preliminaries and semifinal)27 July (final)Competitors43 from 28 nationsWinning points383.40Medalists  He Zi   China Wang Han   China Pamela Ware   Canada← 20112015 → 2013 FINA World ChampionshipsDivingIndividual1 mmenwomen3 mmenwomen10 mmenwomenSynchronised3 mmenwomen10 mmenwomenHigh diving20 mwomen27 mmenOpen water swimming...

The Brave Little Toaster (novel)

1980 novella by Thomas M. Disch This article is about the novel. For the film, see The Brave Little Toaster. The Brave Little Toaster The first publication cover of Thomas M. Disch's The Brave Little Toaster, art by Gahan Wilson.AuthorThomas M. DischCountryUnited StatesLanguageEnglishPublishedAugust 15, 1980 (1980-08-15) The Brave Little Toaster is a 1980 novella by American writer Thomas M. Disch intended for children or, as put by the author, a bedtime story for small applian...

 

 

Begadang (film)

Untuk kegunaan lain, lihat Begadang (disambiguasi). BegadangSutradaraMaman FirmansjahProduserZainal AbidinDitulis olehMaman FirmansyahRhoma IramaPemeranRhoma IramaYati OctaviaBilly ArgoChitra DewiAde IrawanSukarno M. NoorA. Hamid AriefDoddy SukmaYetty LorenKomalasariFakhri AmrullahUrip ArphanPipiet SandraDistributorHanna Internasional FilmTanggal rilis1978Durasi111 menitNegaraIndonesia Begadang adalah film Indonesia yang dirilis pada tahun 1978 dengan disutradarai oleh Maman Firmansjah. Film ...

 

 

بانغور (غوينذ)

  لمعانٍ أخرى، طالع بانغور (توضيح). بانغور (بالإنجليزية: Bangor)‏(بالويلزية: Bangor)‏  الجامعة (أعلى اليمين) والكاتدرائية (الوسط) تقسيم إداري البلد  ويلز المملكة المتحدة[1][2] غوينذ خصائص جغرافية إحداثيات 53°13′41″N 4°07′41″W / 53.228°N 4.128°W / 53.228; -4.128  [...

Abraham George Ellis

Abraham George EllisAbraham George EllisLahir(1846-08-26)26 Agustus 1846 Paramaribo, SurinameMeninggal29 November 1916(1916-11-29) (umur 70) Amsterdam, BelandaPengabdianBelandaDinas/cabang Angkatan Laut Kerajaan BelandaLama dinas1860-1905Pangkat Laksamana mudaPenghargaanKomandan Orde Singa Belanda Abraham George Ellis (26 Agustus 1846 – 29 November 1916) adalah perwira AL dan politikus Belanda. Ellis adalah perwira AL yang pernah menduduki jabatan seperti komandan an...

 

 

Ranulph Crewe

English judge and Chief Justice of the King's Bench (1558–1646) For his grandson, see Randolph Crew (cartographer). This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Ranulph Crewe – news · newspapers · books · scholar · JSTOR (July 2023) (Learn how and when to remove this template message) The Right Honourab...

 

 

Pub

For other uses, see Pub (disambiguation). Public house redirects here. Not to be confused with Public housing. Ye olde pub redirects here. For the plane flown by Charles Brown in WWII, see Charlie Brown and Franz Stigler incident. Establishment that serves alcoholic drinks A thatched country pub, the Williams Arms, near Braunton, Devon, England A city pub, the World's End, Camden Town, London The Ale-House Door (painting of c. 1790 by Henry Singleton) A pub (short for public house) is a drink...

岸信介

岸信介佐藤信介 日本第56、57任內閣總理大臣任期1957年2月25日—1960年7月19日君主昭和天皇副首相石井光次郎益谷秀次前任石橋湛山继任池田勇人 日本內閣總理大臣（臨時代理）任期1957年1月31日—1957年2月25日总理石橋湛山前任石橋湛山继任岸信介 日本防衛廳長官（臨時代理）任期1957年1月31日—1957年2月2日总理岸信介（代，兼）前任石橋湛山（代）继任小瀧彬（�...

 

 

土库曼斯坦总统

土库曼斯坦总统土库曼斯坦国徽土库曼斯坦总统旗現任谢尔达尔·别尔德穆哈梅多夫自2022年3月19日官邸阿什哈巴德总统府（Oguzkhan Presidential Palace）機關所在地阿什哈巴德任命者直接选举任期7年，可连选连任首任萨帕尔穆拉特·尼亚佐夫设立1991年10月27日 土库曼斯坦土库曼斯坦政府与政治 国家政府 土库曼斯坦宪法 国旗 国徽 国歌 立法機關（英语：National Council of Turkmenistan） ...

 

 

Yael Bar Zohar

Yael Bar ZoharBar Zohar in 2007Born (1980-01-29) January 29, 1980 (age 44)Tel Aviv, IsraelSpouse Guy Zu-Aretz ​(m. 2005)​Children3 Yael Bar Zohar (Hebrew: יעל בר זוהר; (1980-01-29)January 29, 1980) is an Israeli television host, model, singer and actress. Early life and career Bar Zohar was born in Tel Aviv, Israel, to a Jewish family. Her Polish-born father Menachem Bar Zohar immigrated to Israel, and he is of Ashkenazi Jewish descent. Her mother El...

Douglas World Cruiser

Berkas:World-cruiser-route01.jpgRute keliling dunia pesawat Douglas World Cruiser Douglas World Cruiser (DWC) dikembangkan untuk memenuhi persyaratan dari Angkatan Darat Amerika Serikat Air Service untuk pesawat yang cocok untuk usaha di penerbangan pertama di seluruh dunia. Douglas Aircraft Company menanggapi dengan varian modifikasi dari pesawat pembom torpedo DT mereka, DWC tersebut. Lima pesawat dipesan untuk penerbangan keliling dunia, satu untuk pengujian dan pelatihan dan empat untuk ...

 

 

Chuda Mani Regmi

Nepalese writer (born 1937) Chuda Mani Upadhaya Regmiचूडामणि रेग्मीRegmi at Folklore Congress NepalBorn (1937-03-11) 11 March 1937 (age 87)Wana, SankhuwasabhaNationalityNepaliOther namesChudamani BandhuOccupation(s)Linguist, writerNotable workKarnali Lok SanskritiSpouse Bed Kumari Dahal ​(m. 1949)​Parents Pitambar Regmi (father) Khileswari Devi(mother) AwardsMadan Puraskar Sajha Puraskar Chuda Mani Upadhaya Regmi (Nepali: चू...

 

 

Maru (蔡英文寵物)

  此條目介紹的是蔡英文的寵物。关于其他用法，请见「Maru」。 Maru基本信息物種家犬品種拉布拉多犬職業導盲犬 （已退役）頭銜第一寵物主人蔡英文（2016年10月15日－）居住地 臺灣臺北市外貌黑色 Maru是蔡英文養的一隻黑色拉布拉多犬，也是一隻退役導盲犬。[1][2][3] 領養過程 蔡英文在「2016年全球導盲犬發展百週年慶暨退役導盲犬收養儀式」上與�...

Jay Obernolte

American politician (born 1970) Jay ObernolteOfficial portrait, 2020Member of theU.S. House of Representativesfrom CaliforniaIncumbentAssumed office January 3, 2021Preceded byPaul CookConstituency8th district (2021–2023)23rd district (2023–present)Member of the California State Assemblyfrom the 33rd districtIn officeDecember 1, 2014 – November 30, 2020Preceded byTim DonnellySucceeded byThurston Smith Personal detailsBornJay Phillip Obernolte (1970-08-18) August 18, 1970 (ag...

 

 

粕川町 (太田市)

日本 > 群馬県 > 太田市 > 粕川町 (太田市) 粕川町 町丁 道の駅おおた 粕川町粕川町の位置群馬県の地図を表示粕川町粕川町 (日本)日本の地図を表示 北緯36度15分50.2912秒 東経139度18分29.6244秒 / 北緯36.263969778度 東経139.308229000度 / 36.263969778; 139.308229000国 日本都道府県  群馬県市町村 太田市地区 尾島地区人口（2022年（令和4年）3月31日現�...

 

 

Clifford Robinson (cestista 1966)

Clifford RobinsonNazionalità Stati Uniti Altezza208 cm Peso109 kg Pallacanestro RuoloAla grande Termine carriera2007 CarrieraGiovanili Riverside High School1985-1989 UConn Huskies Squadre di club 1989-1997 Portland T. Blazers644 (10 405)1997-2001 Phoenix Suns292 (4 775)2001-2003 Detroit Pistons161 (2 158)2003-2005 G.S. Warriors124 (1 326)2005-2007 N.J. Nets159 (927) Il simbolo → indica un trasferimento in prestito.   Modifica dati...

1K17 Sjatie

Cet article est une ébauche concernant le domaine militaire et l’URSS. Vous pouvez partager vos connaissances en l’améliorant (comment ?) selon les recommandations des projets correspondants. 1K17 Szhatie. Le 1K17 Szhatie (en russe : 1К17 Сжатие) est un laser militaire soviétique, mis en œuvre à l'aide du châssis du canon automoteur 2S19 Msta-S. Dans les faits, il s'agit d'une arme à énergie dirigée prenant la forme de douze projecteurs laser montés dans la tou...

 

 

Coccyx

Bone of the pelvis This article is about the tailbone in apes and analogous structures. For animals with tails, see Caudal vertebrae. For the moth genus, see Cydia (genus). Coccyges redirects here. For the clade of birds, see Cuculiformes and Parrot. CoccyxThe coccyxThe coccyx is the final bone in the vertebral column that surrounds the spinal cord.DetailsPronunciation/ˈkɒksɪks/ KOK-siksIdentifiersLatinos coccygisMeSHD003050TA98A02.2.06.001TA21092FMA20229Anatomical terms of bone[edit o...