普托馬尼

普托馬尼
臨床資料
商品名（英语：Drug nomenclature）Dovprela
其他名稱PA-824
AHFS/Drugs.comMonograph
MedlinePlusa619056
核准狀況
给药途径口服给药
ATC碼
法律規範狀態
法律規範
识别信息
  • (6S)-2-Nitro-6[4-(trifluoromethoxy)benzyl]oxy6,7-dihydro-5H-imidazo[2,1-b] [1,3]oxazine
CAS号187235-37-6
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)
化学信息
化学式C14H12F3N3O5
摩尔质量359.26 g·mol−1
3D模型（JSmol（英语：JSmol））
  • C1[C@@H](COC2=NC(=CN21)[N+](=O)[O-])OCC3=CC=C(C=C3)OC(F)(F)F
  • InChI=1S/C14H12F3N3O5/c15-14(16,17)25-10-3-1-9(2-4-10)7-23-11-5-19-6-12(20(21)22)18-13(19)24-8-11/h1-4,6,11H,5,7-8H2/t11-/m0/s1 ☒N
  • Key:ZLHZLMOSPGACSZ-NSHDSACASA-N ☒N

普托馬尼（Pretomanid）用于治疗影响肺部的多重抗藥性結核病（英语：Multidrug-resistant tuberculosis）[4]。是一種口服给药的抗生素[5]。 常与貝達喹啉和利奈唑胺合併使用[5]。

常见副作用包括周邊神經病變、痤疮、呕吐、头痛、低血糖、腹泻和肝炎[4]。其他副作用包括可能骨髓抑制、視神經炎（英语：Optic neuropathy）和QT間期延長（英语：Drug-induced QT prolongation）[6]。娠期的安全性仍不清楚[7]。此药属于5-硝基咪唑类药物[8]。

普托馬尼分別于2019年及2020年在美国及歐洲取得医疗使用許可[4] [5]。名列世界卫生组织基本药物标准清单[9]。此藥是由結核病聯盟（英语：TB Alliance）研发[8] [4]。

参考文獻

  1. ^ Pretomanid tablet. DailyMed. 15 September 2019 [25 September 2020]. 
  2. ^ Dovprela (previously Pretomanid FGK) EPAR. European Medicines Agency (EMA). 24 March 2020 [25 September 2020].  Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  3. ^ Dovprela Product information. Union Register of medicinal products. [3 March 2023]. 
  4. ^ 4.0 4.1 4.2 4.3 FDA approves new drug for treatment-resistant forms of tuberculosis that affects the lungs. U.S. Food and Drug Administration (FDA) (新闻稿). 14 August 2019 [28 August 2019]. （原始内容存档于19 August 2019）.  公有领域 本文含有此來源中屬於公有领域的内容。
  5. ^ 5.0 5.1 5.2 Pretomanid FGK EPAR. European Medicines Agency (EMA). 24 March 2020 [25 September 2020]. （原始内容存档于20 October 2020）.  互联网档案馆的存檔，存档日期20 October 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  6. ^ Pretomanid Monograph for Professionals. Drugs.com. [29 October 2021] （英语）. 
  7. ^ Pretomanid Use During Pregnancy. Drugs.com. [29 October 2021] （英语）. 
  8. ^ 8.0 8.1 Our Pipeline. TB Alliance. [18 April 2019]. （原始内容存档于7 April 2019）.  互联网档案馆的存檔，存档日期7 April 2019.
  9. ^ World Health Organization. The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. 2023. WHO/MHP/HPS/EML/2023.02.