布莱兹反应

布莱兹反应（法語：Réaction de Blaise），是一类由α-卤代酯与锌形成的有机锌试剂与腈加成[1][2][3] ，经过烯胺酯（插烯氨基甲酸酯）生成β-酮酯的反应[4]。

布莱兹反应
布莱兹反应

日本化学家岸义人研究发现，使用活化的锌和四氢呋喃作溶剂可以提高反应收率和减少副反应发生。并用改良的步骤于贝类毒素（或称石房蛤毒素，英文：Saxitoxin）关键中间体的合成[5]。通过使用锌银合金和超声波，美国化学家艾伯特·梅耶斯（Albert Meyers）在温和的条件下（25-40℃）成功进行了分子内布莱兹反应进而完成了某些生物碱的不对称合成[6]。

参见

参考资料

  1. ^ Edmond E. Blaise; Compt. Rend. 1901, 132, 478, 978.
  2. ^ Rinehart, K. L., Jr. Organic Syntheses, Coll. Vol. 4, p.120 (1963); Vol. 35, p.15 (1955).
  3. ^ Rao, H. S. P.; Rafi, S.; Padmavathy, K. Tetrahedron 2008, 64, 8037-8043. (Review)
  4. ^ Cason, J.; Rinehart, K. L., Jr.; Thorston, S. D., Jr. J. Org. Chem. 1953, 18, 1594.
  5. ^ Hannick,S.M.;Kishi,Y.J.Org.Chem.1983,48,3833.
  6. ^ Beard,R.L.;Meyers,A.I.J.Org.Chem.1991,56,2091

Read other articles:

2048 (permainan)

Untuk Tahun, lihat 2048.2048 Logo 2048 Tipepermainan video sumber bebas atau terbuka Versi pertama9 Maret 2014[1]GenreTebakanLisensilisensi MIT Bahasa Daftar Inggris 60 Karakteristik teknisSistem operasiiOS dan Android Platformperamban web, Nintendo 3DS, Apple TV, KaiOS, Android dan iOS ModePermainan video pemain tunggal Formatunduhan digital Metode inputlayar sentuh Bahasa pemrogramanJavascript Format kode Daftar 30 Informasi pengembangPengembangGabriele CirulliPenerbitNintendo eShop...

 

Eko Daniyanto

Artikel ini sebatang kara, artinya tidak ada artikel lain yang memiliki pranala balik ke halaman ini.Bantulah menambah pranala ke artikel ini dari artikel yang berhubungan atau coba peralatan pencari pranala.Tag ini diberikan pada November 2022. Eko Daniyanto Dirtipidnarkoba Bareskrim PolriMasa jabatan14 November 2016 – 2 Februari 2020 PendahuluDharma PongrekunPenggantiKrisno Halomoan Siregar Informasi pribadiLahir15 Maret 1963 (umur 61)JakartaAlma materAkademi Kepolisian (198...

 

Guerre du Pacifique (1879-1884)

Pour les articles homonymes, voir Guerre du Pacifique (homonymie). Guerre du Pacifique Informations générales Date 1879–1883 Lieu Côte pacifique de l'Amérique du Sud au large du Pérou et de la Bolivie Casus belli Approbation d'un contrat entre la Bolivie et la Compagnie de salpêtre et chemins de fer d'Antofagasta en échange du paiement d'une taxe de 10 centimes par quintal de salpêtre exporté de Bolivie Issue Victoire chilienne Changements territoriaux Le Chili annexe le départem...

Keasinan tanah

Tanah yang mengalami salinisasi parah di Colorado. Garam terlarut yang berada di dalam tanah terakumulasi ke permukaan karena kekeringan Keasinan tanah adalah kandungan garam garam yang berada di tanah. Proses peningkatan kadar garam disebut dengan salinisasi.[1] Garam adalah senyawa alami yang berada di tanah dan air. Salinisasi dapat disebabkan oleh proses alami seperti pencucian mineral atau penarikan deposit garam dari lautan. Salinisasi juga bisa terjadi karena kegiatan manusia s...

 

Gilberto Gil

Gilberto GilInformasi latar belakangNama lahirGilberto Passos Gil MoreiraLahir26 Juni 1942 (umur 81) Salvador, Bahia, BrasilGenreMúsica Popular BrasileiraPekerjaanPemusik, penyanyi, pemain gitarTahun aktif1963–sekarangSitus webhttp://www.gilbertogil.com.br/ Gilberto Gil (lahir 26 Juni 1942) adalah seorang pemusik dan politikus berkebangsaan Brasil. Berkarier di dunia musik sejak tahun 1963, dan dia menjadi yang terkenal saat menyanyikan lagu-lagu Música Popular Brasileira. Diskografi...

 

Kokopelli's Trail

Multi-use trail in Grand County, Utah and Mesa County, Colorado, U.S. Kokopelli's TrailCyclist in the McInnis Canyons National Conservation Area along the Kokopelli's Trail in Colorado, July 2013Length142 miles (229 km)LocationGrand County, Utah and Mesa County, Colorado in the United StatesEstablished1989UseMountain bikng, hikingHighest point8,400 feet (2,600 m)Lowest point4,000 feet (1,200 m)Seasonmid-June–September (for higher elevations)[1]SurfaceVaried The Ko...

Malcolm X and Dr. Betty Shabazz Memorial and Educational Center

Memorial in Manhattan, New York 40°50′21″N 73°56′26″W / 40.83917°N 73.94056°W / 40.83917; -73.94056 Entrance to the Shabazz Center The Malcolm X and Dr. Betty Shabazz Memorial and Educational Center, also called the Shabazz Center, is a memorial to Malcolm X and Betty Shabazz located at 3940 Broadway and West 165th Street in the Washington Heights neighborhood of Manhattan, New York City. The building which once housed the Audubon Ballroom, where Malcolm X ...

 

Black Russian

Cocktail of vodka and coffee liqueur This article is about a cocktail. For African diaspora in Russia, see Afro-Russian. For other uses, see Black Russian (disambiguation). Black RussianIBA official cocktailA black Russian cocktailTypeCocktailBase spirit Vodka ServedOn the rocks: poured over iceStandard drinkware Old fashioned glassIBA specifiedingredients† 50 ml Vodka 20 ml Coffee liqueur PreparationPour the ingredients into the old fashioned glass filled with ice cubes. Stir gen...

 

Distintivo di pilota

Distintivo di pilotaDistintivo di pilota Terzo ReichTipoDistintivo di specialità StatusCessato CapoHermann Göring IstituzioneBerlino, 12 agosto 1935 CessazioneBerlino, 1945 Concessa aMilitari tedeschi DiametroAltezza della corona: 53 mm - Larghezza: 42 mm.La larghezza dell'apertura alare dell'aquila misura circa 65 mm Manuale Il distintivo di pilota (in tedesco Flugzeugführerabzeichen) fu una decorazione militare del Terzo Reich, concessa ai militari tedeschi in possesso di brevetto di pil...

Messier 69

Messier 69M69 difoto dari Hubble Space Telescope; 3.5′ Kredit: NASA/STScI/WikiSkyData pengamatan (J2000 epos)KelasV[1]Rasi bintangSagittariusAsensio rekta 18j 31m 23.10d[2]Deklinasi −32° 20′ 53.1″[2]Jarak29.7 ribu tcMagnitudo tampak (V)+8.31[3]Dimensi tampak (V)9′.8Karakteristik fisikRadius42 tc[4]MetalisitasTemplat:Fe/H dexPerkiraan umur13.06  Miliar tahun[5]Nama lainM69, NGC 6637, GCl 96[3]...

 

Henry Herbert, 4th Earl of Carnarvon

British aristocrat (1831–1890) The Right HonourableThe Earl of CarnarvonKP PC DL FRS FSAPortrait of the Henry Herbert, the 4th Earl of Carnarvon, c. 1880Lord Lieutenant of HampshireIn office6 August 1887 – 29 June 1890MonarchVictoriaPreceded byThe Marquess of WinchesterSucceeded byThe Earl of NorthbrookSecretary of State for the ColoniesIn office6 July 1866 – 8 March 1867MonarchQueen VictoriaPrime MinisterThe Earl of DerbyPreceded byEdward Cardwel...

 

Shortening

Food ingredient This article is about the food ingredient. For shortened forms of words, see Clipping (morphology). Strutto, or clarified pork fat, or lard, a type of shortening common in Italy and Corsica (where it is named sdruttu) Shortening is any fat that is a solid at room temperature and is used to make crumbly pastry and other food products. The idea of shortening dates back to at least the 18th century, well before the invention of modern, shelf-stable vegetable shortening.[1]...

Pokémon GO Battle League

Gameplay element of Pokémon GO The cover logo for the GO Battle League The GO Battle League (Japanese: GOバトルリーグ GO Battle League), sometimes shortened to the GBL, is a feature in Pokémon GO which allows for competitive, online trainer battles. This was introduced by Niantic on January 28, 2020.[1] The GO Battle League takes course over a Battle League Season[2] so that the league can provide different tournaments, cups, and rewards each and every season. Only tra...

 

كأس ألبانيا

كأس ألبانيا معلومات عامة الرياضة كرة القدم انطلقت 1939 البلد ألبانيا  المنظم اتحاد ألبانيا لكرة القدم  المنطقة  ألبانيا التواتر 1 سنة  عدد المشاركين 38 الموقع الرسمي كأس ألبانيا قائمة الفائزين آخر بطل فلازنيا شكودر (اللقب السابع) الأكثر تتويجًا تيرانا (16 لقبًا) التس...

 

مقياس رسم

مقياس رسممعلومات عامةصنف فرعي من مقياس الرسمكمية لا بعدية جزء من الخرائطية الاستعمال خريطة plan (en) topographic profile (en) الكرة الأرضية تعديل - تعديل مصدري - تعديل ويكي بيانات مقياس رسم الخريطة هو نسبة ما بين الابعاد على الطبيعة والأبعاد على الخريطة حيث تمثل الابعاد الحقيقة الطبيعية ...

История почты и почтовых марок Мавритании

Исламская Республика Мавританияфр. République Islamique de Mauritanieараб. الجمهورية الإسلامية الموريتانية‎ Почтовая марка Мавритании,1913 (Sc #19) История почты Член ВПС с 22 марта 1967 (республика) Почтовые администрации Французская Западная Африка 1 французский франк = 100 сантимов (...

 

Club Brujas

BrujasDatos generalesNombre Club Brugge Koninklijke VoetbalverenigingApodo(s) Blauw-Zwart (Azul-Negro)The AcademyFundación 13 de noviembre de 1891 (132 años)Colores          Presidente Bart VerhaegheEntrenador Nicky HayenInstalacionesEstadio Jan BreydelCapacidad 29 472Ubicación Brujas, BélgicaInauguración 1975Uniforme Titular Alternativo Última temporadaLiga Pro League(2023-24) CampeónTítulos 19 (por última vez en 2023-24)Copa Copa de...

 

Trattato di Batumi

Trattato di BatumiFirma4 giugno 1918 LuogoBatumi CondizioniCaduta del governo della Federazione Rivoluzionaria Armena Parti Impero ottomano Prima Repubblica di Armenia FirmatariImpero ottomanoRepubblica Democratica di ArmeniaRepubblica Democratica di Georgia e Repubblica Democratica di Azerbaigian voci di trattati presenti su Wikipedia Il trattato di Batumi è stato un trattato di pace tra la Prima Repubblica di Armenia e l'Impero ottomano, firmato a Batumi il 4 giugno 1918. È stato il ...

Eurasian Youth Union

Political organization in Russia Eurasian Youth Union Евразийский союз молодёжиAbbreviationESM (English)ЕСМ (Russian)LeaderAleksandr DuginChairpersonPavel KanishchevAlexander BovdunovFounded26 February 2005; 19 years ago (2005-02-26)Headquarters7th Building, Tverskaya Street, Moscow, Russia. 125375NewspaperEurasian InvasionIdeology Neo-Eurasianism National Bolshevism Russian irredentism Traditionalist conservatism Anti-Western sentiment Political...

 

USS Lejeune

History Germany NameWindhuk OperatorDeutsche Ost-Afrika Linie[1] Port of registryBremen BuilderBlohm+Voss, Hamburg Yard number507 Completed1936[1] Identification call sign DJTH FateInterned in Brazil August 1942 United States NameUSS Lejeune (AP-74) NamesakeJohn Archer Lejeune OperatorUnited States Navy Acquired12 August 1942 Commissioned12 May 1944 Decommissioned9 February 1948 StrickenJuly 1957 FateScrapped, 1966 General characteristics Tonnage16,662 GRT[1] Len...