四硫代钼酸胆碱

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四硫代钼酸胆碱
臨床資料
商品名（英语：Drug nomenclature）Decuprate
其他名稱四硫代钼酸双胆碱
双胆碱四硫代钼酸盐
ATN-224、WTX101
ATC碼
  • 未分配
法律規範狀態
法律規範
  • Investigational
识别信息
CAS号649749-10-0  ☒N
PubChem CID
DrugBank
ChemSpider
UNII
化学信息
化学式C10H28MoN2O2S4
摩尔质量432.542 g/mol
3D模型（JSmol（英语：JSmol））
  • OCC[N+](C)(C)C.[S-][Mo]([S-])(=S)=S.C[N+](C)(C)CCO
  • InChI=1S/2C5H14NO.Mo.4S/c2*1-6(2,3)4-5-7;;;;;/h2*7H,4-5H2,1-3H3;;;;;/q2*+1;;;;2*-1
  • Key:NEYVHGQOGHJAAD-UHFFFAOYSA-N

四硫代钼酸胆碱（又称胆碱四硫代钼酸盐，商品名为Decuprate），是胆碱所形成的硫代钼酸盐（TTM, MoS42−）。作为威尔逊氏病的治疗方法，这是一种身体不能调节铜的罕见且潜在的致命疾病。威尔逊病是一种常染色体隐性遗传性疾病，有严重的肝、神经或精神症状的表现。若未经诊断和未经治疗，该疾病可能致命。据估计，全世界每3万人中约有1人患有威尔逊氏病，相当于欧盟约有1万5千人而美国约有1万1千人。[1]

已经在患有各种癌症的患者的临床试验中评估了四硫代钼酸胆碱，[2][3][4]并在美国和欧盟成为了孤儿药（即罕见药），作为威尔逊氏病的潜在治疗方法。[5][6]

四硫代钼酸胆碱是威尔逊治疗学公司的代号为WTX101的威尔逊氏病临床开发中的去铜疗法用药，该公司由HealthCap于2012年成立。

参考文献

  1. ^ Ala, A; Walker, A. P.; Ashkan, K; Dooley, J. S.; Schilsky, M. L. Wilson's disease. The Lancet. 2007, 369 (9559): 397–408. PMID 17276780. doi:10.1016/S0140-6736(07)60196-2. 
  2. ^ Berenson JR, Boccia RV, Bashey A, Levine AM, Koc ON, Callahan JA, Mazar AP, Reich SD. Phase I Study of the [Cu, Zn] Superoxide Dismutase (SOD1) Inhibitor ATN-224 (Bis-Choline Tetrathiomolybdate) in Patients with Advanced Hematologic Malignancies Presentation at the Amer Soc Hematol 2006 Annual Meeting. Blood. 2006, 108. Abstract 2593. 
  3. ^ Lin, J; Zahurak, M; Beer, T. M.; Ryan, C. J.; Wilding, G; Mathew, P; Morris, M; Callahan, J. A.; Gordon, G; Reich, S. D.; Carducci, M. A.; Antonarakis, E. S. A non-comparative randomized phase II study of 2 doses of ATN-224, a copper/zinc superoxide dismutase inhibitor, in patients with biochemically recurrent hormone-naïve prostate cancer. Urologic Oncology: Seminars and Original Investigations. 2013, 31 (5): 581–8. PMC 3227793 可免费查阅. PMID 21816640. doi:10.1016/j.urolonc.2011.04.009. 
  4. ^ Lowndes, S. A.; Adams, A; Timms, A; Fisher, N; Smythe, J; Watt, S. M.; Joel, S; Donate, F; Hayward, C; Reich, S; Middleton, M; Mazar, A; Harris, A. L. Phase I study of copper-binding agent ATN-224 in patients with advanced solid tumors. Clinical Cancer Research. 2008, 14 (22): 7526–34. PMID 19010871. doi:10.1158/1078-0432.CCR-08-0315. 
  5. ^ Public summary of opinion on orphan designation: Choline tetrathiomolybdate for the treatment of Wilson's disease （页面存档备份，存于互联网档案馆）, EMA/COMP/795268/2012, ATN-224, 18 February 2013.
  6. ^ Orphan Drug Designations and Approvals: choline tetrathiomolybdate （页面存档备份，存于互联网档案馆）, U.S. Food and Drug Administration, 25 August 2011

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