Monoamin oksidaz

Monoamin oksidaz veya MAO, monoaminlerin oksidasyonunu katalizleyen enzimlerdir.[1][2] Bu enzim Mary Bernheim tarafından ilk olarak karaciğer hücrelerinde tespit edilmiş ve "tyramine oxidase" olarak isimlendirilmiştir.[3][4] Dopamin, norepinefrin ve serotonin gibi amin nörotransmitterlerini parçalar. Bu protein mitokondri dış zarında bulunur. Monoamin oxidaz A ya da MAOA geni tarafından sentezlenir. Monoamin oksidaz eksikliği Brunner sendromuna sebep olur.

MAO-A ve MAO-B olmak üzere ikiye ayrılır. Her ikisi de nöronlarda ve astroglialarda bulunur. Merkezi sinir sistemi dışında, MAO-A ayrıca karaciğer, sindirim sistemi ve plasentada bulunur. MAO-B ise en çok kan pulcuklarında (plateletlerde) bulunur.

Kaynakça

  1. ^ Tipton KF, Boyce S, O'Sullivan J, Davey GP, Healy J (Ağustos 2004). "Monoamine oxidases: certainties and uncertainties". Curr. Med. Chem. 11 (15). ss. 1965-82. PMID 15279561. 
  2. ^ Edmondson DE, Mattevi A, Binda C, Li M, Hubálek F (Ağustos 2004). "Structure and mechanism of monoamine oxidase". Curr. Med. Chem. 11 (15). ss. 1983-93. PMID 15279562. 
  3. ^ Hare ML (1928). "Tyramine oxidase: A new enzyme system in liver". Biochem. J. 22 (4). ss. 968-79. PMC 1252213 $2. PMID 16744124. 
  4. ^ Slotkin TA (1999). "Mary Bernheim and the discovery of monoamine oxidase". Brain Res. Bull. 50 (5–6). s. 373. doi:10.1016/S0361-9230(99)00110-0. PMID 10643441. 

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