16. Screen Actors Guild Awards 2009 yılının oyunculuk dalında sinema ve televizyonda en iyilerine verilen ödül. Ödül töreni 21 Ocak 2010'da Shrine Exposition Center in Los Angeles'ta yapıldı. TNT ve TBS kanallarından yayınlandı.

Adaylar 17 Aralık 2009'da Michelle Monaghan ve Chris O'Donnell tarafından açıklanmıştır.^[1]

• Jeff Bridges – Crazy Heart
• George Clooney – Up In The Air
• Colin Firth – A Single Man
• Morgan Freeman – Invictus
• Jeremy Renner – The Hurt Locker

• Sandra Bullock – The Blind Side
• Helen Mirren – The Last Station
• Carey Mulligan – An Education
• Gabourey Sidibe – Precious
• Meryl Streep – Julie & Julia

• Matt Damon – Invictus
• Woody Harrelson – The Messenger
• Christopher Plummer – The Last Station
• Stanley Tucci – The Lovely Bones
• Christoph Waltz – Inglourious Basterds

• Penelope Cruz – Nine
• Vera Farmiga – Up In The Air
• Anna Kendrick – Up In The Air
• Diane Kruger – Inglourious Basterds
• Mo'Nique – Precious

• An Education
• The Hurt Locker
• Inglourious Basterds
• Nine
• Precious

• Public Enemies
• Star Trek
• Transformers: Revenge of the Fallen

• Kevin Bacon – Taking Chance
• Cuba Gooding, Jr. – Gifted Hands: The Ben Carson Story
• Jeremy Irons – Georgia O'Keeffe
• Kevin Kline – Great Performances: Cyrano de Bergerac
• Tom Wilkinson – A Number

• Joan Allen – Georgia O'Keeffe
• Drew Barrymore – Grey Gardens
• Ruby Dee – America
• Jessica Lange – Grey Gardens
• Sigourney Weaver – Prayers for Bobby

• Simon Baker – The Mentalist
• Bryan Cranston – Breaking Bad
• Michael C. Hall – Dexter
• Jon Hamm – Mad Men
• Hugh Laurie – House

• Patricia Arquette – Medium
• Glenn Close - Damages
• Mariska Hargitay – Law & Order: Special Victims Unit
• Holly Hunter – Saving Grace
• Julianna Margulies – The Good Wife
• Kyra Sedgwick – The Closer

• Alec Baldwin – 30 Rock
• Steve Carell – The Office
• Larry David – Curb Your Enthusiasm
• Tony Shalhoub – Monk
• Charlie Sheen – Two and a Half Men

• Christina Applegate – Samantha Who?
• Toni Collette – United States of Tara
• Edie Falco – Nurse Jackie
• Tina Fey – 30 Rock
• Julia Louis-Dreyfus – The New Adventures of Old Christine

• The Closer
• Dexter
• The Good Wife
• Mad Men
• True Blood

• 30 Rock
• Curb Your Enthusiasm
• Glee
• Modern Family
• The Office

• 24
• The Closer
• Dexter
• Heroes
• The Unit