Ang Unibersidad ng San Carlos de Guatemala (USAC, Ingles: University of San Carlos ng Guatemala; Espanyol: Universidad de San Carlos de Guatemala) ay ang pinakamalaki at pinakamatandang unibersidad sa bansang Guatemala; ito rin ang ika-apat na unibersidad na itinatag sa Kaamerikahan. Itinatag noong panahon ng pananakop ng Espanya, ito ay ang pinakaprestihiyosong institusyon ng mas mataas na edukasyon sa Gitnang Amerika — at nag-iisang unibersidad sa Guatemala hanggang 1954.

Ang Unibersidad ay nagkaroon ng limang mga pangunahing pagbabago:

• Maharlika at Pontifikal na Unibersidad ng San Carlos Borromeo (Ingles - Royal and Pontifical University of San Carlos Borromeo): 1676-1829
• Academia de Ciencias: 1834-1840
• Pontifikal na Unibersidad ng San Carlos Borromeo (Ingles: Pontifical University of San Carlos Borromeo): 1840–1875
• Pambansang Unibersidad ng Guatemala (Ingles: National University of Guatemala): 1875–1944
• Unibersidad ng San Carlos de Guatemala: 1944-

#	Name	Acronym	Website
1	College of Agriculture	FAUSAC	fausac.edu.gt Naka-arkibo 2008-09-05 sa Wayback Machine.
2	College of Architecture	FARUSAC	farusac.com/ Naka-arkibo 2017-10-04 sa Wayback Machine.
3	College of Economic Sciences	Economics	caeconomicas.usac.edu.gt Naka-arkibo 2015-07-03 sa Wayback Machine.
4	College of Law	Law	derecho.usac.edu.gt Naka-arkibo 2021-04-24 sa Wayback Machine. derecho.usac.edu.gt
5	College of Medicine	Medicine	medicina.usac.edu.gt medicina.usac.edu.gt
6	College of Pharmacy	Pharmacy	ccqqfar.usac.edu.gt Naka-arkibo 2015-06-23 sa Wayback Machine. ccqqfar.usac.edu.gt
7	College of Humanities	FAHUSAC	fahusac.edu.gt Naka-arkibo 2012-05-04 sa Wayback Machine.
8	College of Engineering	FIUSAC	ingeniería.usac.edu.gt
9	College of Dental Medicine	Dental College	odontologia.usac.edu.gt odontologia.usac.edu.gt
10	College of Veterinary and Animal Studies	Veterinary	fmvz.usac.edu.gt fmvz.usac.edu.gt

#	Paaralan	Acronym	Website
1	School of Physical Education	ECTAFIDE
2	Political Sciences School	ECP
3	Communication Sciences School	ECC	comunicacionusac.org Naka-arkibo 2017-03-28 sa Wayback Machine.
4	Language Sciences School	ECL
5	School of Psychology
6	School of Infirmary
7	High School Teacher School	EFPEM	efpem.usac.edu.gt efpem.usac.edu.gt
8	School of History		escuelahistoria.usac.edu.gt Naka-arkibo 2017-03-25 sa Wayback Machine.
9	Superior School of Art	ESA
10	School of Social Work		trabajosocial.usac.edu.gt
11	Graphic design school	EDG

#	Regional Center	Acronym	Website
1	Centro Universitario de Occidente	CUNOC	Quetzaltenango, Quetzaltenango
2	Centro Universitario de Izabal	CUNIZAB	Puerto Barrios, Izabal
3	Centro Universitario de Oriente	CUNORI	Chiquimula, Chiquimula
4	Petén Regional Campus	CUDEP	Flores, Petén
5	University Center of the North	CUNOR	Cobán, Alta Verapaz
6	University Center of the Southeast	CUNSURORI
7	Santa Rosa Regional Campus	CUNSARO	Cuilapa, Santa Rosa
8	University Center of the Southwest	CUNSUROC	Mazatenango, Suchitepéquez
9	San Marcos Regional Campus	CUSAM	San Marcos, San Marcos
10	University Center of the Northwest	CUNOROC	La Democracia, Huehuetenango
11	University Center of the South	CUNSUR	Escuintla, Escuintla
12	Chimaltenango Regional Campus	CUNDECH	Chimaltenango, Chimaltenango
13	Jutiapa Regional Campus	JUSAC	Jutiapa Jutiapa
14	Quiche Regional Campus	CUQ	Santa Cruz del Quiché, Quiché
15	Baja Verapaz Regional Campus	CUNBAV	San Miguel Chicaj, Baja Verapaz
16	Totonicapán Regional Campus	CUNTOTO	Chuipachec, Totonicapán
17	Metropolitan Regional Campus	CUM	Guatemala City
18	Sololá Regional Campus	CUNSOL	Sololá, Sololá
19	Ocean Studies Center	CEMA
20	Guatemala Sur Technological Institute	ITUGS	Palín, Escuintla

14°35′N 90°33′W / 14.58°N 90.55°W / 14.58; -90.55 Ang lathalaing ito na tungkol sa Edukasyon ay isang usbong. Makatutulong ka sa Wikipedia sa pagpapalawig nito.