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PMC	članci
PubMed	članci
NCBI	proteini

Transportujuća ATPaza steroida
Transportujuća ATPaza steroida
Identifikatori
EC broj	3.6.3.45
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Transportujuća ATPaza steroida (EC 3.6.3.45, protein pleiotropske otpornosti na lekove, PDR protein) je enzim sa sistematskim imenom ATP fosfohidrolaza (eksport steroida).^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + H₂O + steroid_in

\rightleftharpoons

ADP + fosfat + steroid_out

Ova ATPaza ABC-tipa je karakteristična po prisustvu dva slična ATP-vezujuća domena.

Reference

^ Prasad, R., De Wergifosse, P., Goffeau, A. and Balzi, E. (1995). „Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals”. Curr. Genet. 27: 320—329. PMID 7614555.
^ Nagao, K., Taguchi, Y., Arioka, M., Kadokura, H., Takatsuki, A., Yoda, K. and Yamasaki, M. (1995). „bfr1⁺, a novel gene of Schizosaccharomyces pombe which confers brefeldin A resistance, is structurally related to the ATP-binding cassette superfamily”. J. Bacteriol. 177: 1536—1543. PMID 7883711.
^ Mahé, Y., Lemoine, Y. and Kuchler, K. (1996). „The ATP-binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo”. J. Biol. Chem. 271: 25167—25172. PMID 8810273.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Steroid-transporting+ATPase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Prasad, R., De Wergifosse, P., Goffeau, A. and Balzi, E. (1995). „Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals”. Curr. Genet. 27: 320—329. PMID 7614555.

[2] Nagao, K., Taguchi, Y., Arioka, M., Kadokura, H., Takatsuki, A., Yoda, K. and Yamasaki, M. (1995). „bfr1⁺, a novel gene of Schizosaccharomyces pombe which confers brefeldin A resistance, is structurally related to the ATP-binding cassette superfamily”. J. Bacteriol. 177: 1536—1543. PMID 7883711.

[3] Mahé, Y., Lemoine, Y. and Kuchler, K. (1996). „The ATP-binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo”. J. Biol. Chem. 271: 25167—25172. PMID 8810273.

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