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PubMed	članci
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Tiazolna tautomeraza
Tiazolna tautomeraza
Identifikatori
EC broj	5.3.99.10
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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NCBI	proteini

Tiazolna tautomeraza (EC 5.3.99.10, tenI (gen)) je enzim sa sistematskim imenom 2-(2-karboksi-4-metilthiazol-5-il)etil fosfat izomeraza.^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

2-[(2R,5Z)-2-karboksi-4-metiltiazol-5(2H)-iliden]etil fosfat

\rightleftharpoons

2-(2-karboksi-4-metiltiazol-5-il)etil fosfat

Ovaj enzim katalizuje ireverzibilnu aromatizaciju tiazolne grupe 2-[(2R,5Z)-2-karboksi-4-metiltiazol-5(2H)-iliden]etil fosfata.

Reference

^ Hazra, A.B., Han, Y., Chatterjee, A., Zhang, Y., Lai, R.Y., Ealick, S.E. and Begley, T.P. (2011). „A missing enzyme in thiamin thiazole biosynthesis: identification of TenI as a thiazole tautomerase”. J. Am. Chem. Soc. 133: 9311—9319. PMID 21534620.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Thiazole+tautomerase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Hazra, A.B., Han, Y., Chatterjee, A., Zhang, Y., Lai, R.Y., Ealick, S.E. and Begley, T.P. (2011). „A missing enzyme in thiamin thiazole biosynthesis: identification of TenI as a thiazole tautomerase”. J. Am. Chem. Soc. 133: 9311—9319. PMID 21534620.

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