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Taksan 10b-hidroksilaza
Taksan 10b-hidroksilaza
Identifikatori
EC broj	1.14.13.76
CAS broj	337514-75-7
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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PubMed	članci
NCBI	proteini

Taksan 10b-hidroksilaza (EC 1.14.13.76, taksanska 10b-hidroksilaza) je enzim sa sistematskim imenom taksa-4(20),11-dien-5alfa-il acetat,NADPH:kiseonik oksidoreduktaza (10beta-hidroksilacija).^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

taksa-4(20),11-dien-5alfa-il acetat + NADPH + H⁺ + O₂

\rightleftharpoons

10beta-hidroksitaksa-4(20),11-dien-5alfa-il acetat + NADP⁺ +H₂O

Ovaj mikrozomalni citohrom-P450-zavisni enzim učestvuje u biosinteza diterpenoidnog antineoplastičnog leka taksola (paklitaksela).

Reference

^ Wheeler, A.L., Long, R.M., Ketchum, R.E., Rithner, C.D., Williams, R.M. and Croteau, R. (2001). „Taxol biosynthesis: differential transformations of taxadien-5α-ol and its acetate ester by cytochrome P₄₅₀ hydroxylases from Taxus suspension cells”. Arch. Biochem. Biophys. 390: 265—78. PMID 11396929.
^ Jennewein, S., Rithner, C.D., Williams, R.M. and Croteau, R.B. (2001). „Taxol biosynthesis: taxane 13 α-hydroxylase is a cytochrome P₄₅₀-dependent monooxygenase”. Proc. Natl. Acad. Sci. USA. 98: 13595—13560. PMID 11707604.
^ Schoendorf, A., Rithner, C.D., Williams, R.M. and Croteau, R.B. (2001). „Molecular cloning of a cytochrome P₄₅₀ taxane 10β-hydroxylase cDNA from Taxus and functional expression in yeast”. Proc. Natl. Acad. Sci. USA. 98: 1501—1506. PMID 11171980.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Taxane+10beta-hydroxylase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Wheeler, A.L., Long, R.M., Ketchum, R.E., Rithner, C.D., Williams, R.M. and Croteau, R. (2001). „Taxol biosynthesis: differential transformations of taxadien-5α-ol and its acetate ester by cytochrome P₄₅₀ hydroxylases from Taxus suspension cells”. Arch. Biochem. Biophys. 390: 265—78. PMID 11396929.

[2] Jennewein, S., Rithner, C.D., Williams, R.M. and Croteau, R.B. (2001). „Taxol biosynthesis: taxane 13 α-hydroxylase is a cytochrome P₄₅₀-dependent monooxygenase”. Proc. Natl. Acad. Sci. USA. 98: 13595—13560. PMID 11707604.

[3] Schoendorf, A., Rithner, C.D., Williams, R.M. and Croteau, R.B. (2001). „Molecular cloning of a cytochrome P₄₅₀ taxane 10β-hydroxylase cDNA from Taxus and functional expression in yeast”. Proc. Natl. Acad. Sci. USA. 98: 1501—1506. PMID 11171980.

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