PROFILPELAJAR.COM

Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

TRNK nukleotidiltransferaza
TRNK nukleotidiltransferaza
	RNaza PH hexamer, Pseudomonas aeruginosa
Identifikatori
EC broj	2.7.7.56
CAS broj	116412-36-3
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

TRNK nukleotidiltransferaza (EC 2.7.7.56, fosfat-zavisna eksonukleaza, RNaza PH, ribonukleaza PH) je enzim sa sistematskim imenom tRNK:fosfat nukleotidiltransferaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

tRNK_n+1 + fosfat

\rightleftharpoons

tRNK_n + nukleozid difosfat

Ovaj enzim vrši finalno eksonukleolitičko odsecanje na 3'-terminusu tRNK prekurzora kod Escherichia coli putem fosforolize.

Reference

^ Cudny, H. & Deutscher, M.P. (1988). „3′ processing of tRNA precursors in ribonuclease-deficient Escherichia coli. Development and characterization of an in vitro processing system and evidence for a phosphate requirement”. J. Biol. Chem. 263: 1518—1523. PMID 3275667.
^ Deutscher, M.P., Marshall, G.T. and Cudny, H. (1988). „RNase PH: an Escherichia coli phosphate-dependent nuclease distinct from polynucleotide phosphorylase”. Proc. Natl. Acad. Sci. USA. 85: 4710—4714. PMID 2455297.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

TRNA+nucleotidyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Cudny, H. & Deutscher, M.P. (1988). „3′ processing of tRNA precursors in ribonuclease-deficient Escherichia coli. Development and characterization of an in vitro processing system and evidence for a phosphate requirement”. J. Biol. Chem. 263: 1518—1523. PMID 3275667.

[2] Deutscher, M.P., Marshall, G.T. and Cudny, H. (1988). „RNase PH: an Escherichia coli phosphate-dependent nuclease distinct from polynucleotide phosphorylase”. Proc. Natl. Acad. Sci. USA. 85: 4710—4714. PMID 2455297.

[1]

[2]