PROFILPELAJAR.COM

Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Sve-trans-retinil-palmitatna hidrolaza
Sve-trans-retinil-palmitatna hidrolaza
Identifikatori
EC broj	3.1.1.64
CAS broj	106389-24-6
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Sve-trans-retinil-palmitatna hidrolaza (EC 3.1.1.64, sve-trans-retinil-palmitat hidrolaza, sve-trans-retinol izomeraza:hidrolaza, sve-trans-retinilestar 11-cis izomerohidrolaza, RPE65 (gen)) je enzim sa sistematskim imenom sve-trans-retinil estar acilhidrolaza, formira 11-cis retinol.^[1]^[2]^[3]^[4]^[5]^[6] Ovaj enzim katalizuje sledeću hemijsku reakciju

sve-trans-retinil estar + H₂O

\rightleftharpoons

11-cis-retinol + masna kiselina

Ovaj enzim, koji deluje u retinalnom pigmentnom epitelu (RPE), katalizuje razlaganje i izomerizaciju sve-trans-retinil masno kiselinskih estara do 11-cis-retinola.

Reference

^ Blaner, W.S., Das, S.R., Gouras, P. and Flood, M.T. (1987). „Hydrolysis of 11-cis- and all-trans-retinyl palmitate by homogenates of human retinal epithelial cells”. J. Biol. Chem. 262: 53—58. PMID 3793734.
^ Bernstein, P.S., Law, W.C. and Rando, R.R. (1987). „Isomerization of all-trans-retinoids to 11-cis-retinoids in vitro”. Proc. Natl. Acad. Sci. USA. 84: 1849—1853. PMID 3494246.
^ Bridges, C.D. & Alvarez, R.A. (1987). „The visual cycle operates via an isomerase acting on all-trans retinol in the pigment epithelium”. Science. 236: 1678—1680. PMID 3603006.
^ Moiseyev, G., Chen, Y., Takahashi, Y., Wu, B.X. and Ma, J.X. (2005). „RPE65 is the isomerohydrolase in the retinoid visual cycle”. Proc. Natl. Acad. Sci. USA. 102: 12413—12418. PMID 16116091.
^ Nikolaeva, O., Takahashi, Y., Moiseyev, G. and Ma, J.X. (2009). „Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane”. FEBS J. 276: 3020—3030. PMID 19490105.
^ Golczak, M., Kiser, P.D., Lodowski, D.T., Maeda, A. and Palczewski, K. (2010). „Importance of membrane structural integrity for RPE65 retinoid isomerization activity”. J. Biol. Chem. 285: 9667—9682. PMID 20100834.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Retinoid+isomerohydrolase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Blaner, W.S., Das, S.R., Gouras, P. and Flood, M.T. (1987). „Hydrolysis of 11-cis- and all-trans-retinyl palmitate by homogenates of human retinal epithelial cells”. J. Biol. Chem. 262: 53—58. PMID 3793734.

[2] Bernstein, P.S., Law, W.C. and Rando, R.R. (1987). „Isomerization of all-trans-retinoids to 11-cis-retinoids in vitro”. Proc. Natl. Acad. Sci. USA. 84: 1849—1853. PMID 3494246.

[3] Bridges, C.D. & Alvarez, R.A. (1987). „The visual cycle operates via an isomerase acting on all-trans retinol in the pigment epithelium”. Science. 236: 1678—1680. PMID 3603006.

[4] Moiseyev, G., Chen, Y., Takahashi, Y., Wu, B.X. and Ma, J.X. (2005). „RPE65 is the isomerohydrolase in the retinoid visual cycle”. Proc. Natl. Acad. Sci. USA. 102: 12413—12418. PMID 16116091.

[5] Nikolaeva, O., Takahashi, Y., Moiseyev, G. and Ma, J.X. (2009). „Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane”. FEBS J. 276: 3020—3030. PMID 19490105.

[6] Golczak, M., Kiser, P.D., Lodowski, D.T., Maeda, A. and Palczewski, K. (2010). „Importance of membrane structural integrity for RPE65 retinoid isomerization activity”. J. Biol. Chem. 285: 9667—9682. PMID 20100834.

[1]

[2]

[3]

[4]

[5]

[6]