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PubMed	članci
NCBI	proteini

Sfingomijelinska deacilaza
Sfingomijelinska deacilaza
Identifikatori
EC broj	3.5.1.109
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Sfingomijelinska deacilaza (EC 3.5.1.109, SM deacilaza, GcSM deacilaza, glukozilkeramid sfingomijelinska deacilaza, sfingomijelin glukozilkeramidna deacilaza, SM glukozilkeramid GCer deacilaza, SM-GCer deacilaza, SMGCer deacilaza) je enzim sa sistematskim imenom N-acil-sfingozilfosforilholin amidohidrolaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) N-acil-sfingozilfosforilholin + H₂O

\rightleftharpoons

masna kiselina + sfingozilfosforilholin;;

(2) D-glukozil-N-acilsfingozin + H₂O

\rightleftharpoons

masna kiselina + D-glukozil-sfingozin

Ovaj enzim učestvuje u sfingolipidnom metabolizmu u epidermisu.

Reference

^ Hara, J., Higuchi, K., Okamoto, R., Kawashima, M. and Imokawa, G. (2000). „High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis”. J. Invest. Dermatol. 115: 406—413. PMID 10951276.
^ Higuchi, K., Hara, J., Okamoto, R., Kawashima, M. and Imokawa, G. (2000). „The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide”. Biochem. J. 350: 747—756. PMID 10970788.
^ Ishibashi, M., Arikawa, J., Okamoto, R., Kawashima, M., Takagi, Y., Ohguchi, K. and Imokawa, G. (2003). „Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis”. Lab. Invest. 83: 397—408. PMID 12649340.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Sphingomyelin+deacylase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Hara, J., Higuchi, K., Okamoto, R., Kawashima, M. and Imokawa, G. (2000). „High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis”. J. Invest. Dermatol. 115: 406—413. PMID 10951276.

[2] Higuchi, K., Hara, J., Okamoto, R., Kawashima, M. and Imokawa, G. (2000). „The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide”. Biochem. J. 350: 747—756. PMID 10970788.

[3] Ishibashi, M., Arikawa, J., Okamoto, R., Kawashima, M., Takagi, Y., Ohguchi, K. and Imokawa, G. (2003). „Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis”. Lab. Invest. 83: 397—408. PMID 12649340.

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