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S-formilglutationska hidrolaza
S-formilglutationska hidrolaza
Identifikatori
EC broj	3.1.2.12
CAS broj	83380-83-0
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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S-formilglutationska hidrolaza (EC 3.1.2.12, S-formylglutathione hydrolase) je enzim sa sistematskim imenom S-formilglutation hidrolaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

S-formilglutation + H₂O

\rightleftharpoons

glutation + format

Ovaj enzim takođe u manjoj meri hidrolizuje S-acetilglutation.

Reference

^ Uotila, L. (1973). „Preparation and assay of glutathione thiol esters. Survey of human liver glutathione thiol esterases”. Biochemistry. 12: 3938—3943. PMID 4200890.
^ Uotila, L. & Koivusalo, M. (1974). „Purification and properties of S-formylglutathione hydrolase from human liver”. J. Biol. Chem. 249: 7664—7672. PMID 4436331.
^ Harms, N., Ras, J., Reijnders, W.N., van Spanning, R.J. and Stouthamer, A.H. (1996). „S-Formylglutathione hydrolase of Paracoccus denitrificans is homologous to human esterase D: a universal pathway for formaldehyde detoxification?”. J. Bacteriol. 178: 6296—6299. PMID 8892832.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

S-formylglutathione+hydrolase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Uotila, L. (1973). „Preparation and assay of glutathione thiol esters. Survey of human liver glutathione thiol esterases”. Biochemistry. 12: 3938—3943. PMID 4200890.

[2] Uotila, L. & Koivusalo, M. (1974). „Purification and properties of S-formylglutathione hydrolase from human liver”. J. Biol. Chem. 249: 7664—7672. PMID 4436331.

[3] Harms, N., Ras, J., Reijnders, W.N., van Spanning, R.J. and Stouthamer, A.H. (1996). „S-Formylglutathione hydrolase of Paracoccus denitrificans is homologous to human esterase D: a universal pathway for formaldehyde detoxification?”. J. Bacteriol. 178: 6296—6299. PMID 8892832.

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