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RFC1
Available structures
PDB	Pretraga ortologa: PDBe RCSB
List of PDB id codes
	2EBU, 2K6G, 2K7F
Identifikatori
Alijasi	RFC1
Spoljašnji ID	OMIM: 102579 MGI: 97891 HomoloGene: 2187 GeneCards: RFC1
Genska lokacija (miš)
Hr.	Chromosome 5 (mouse)
Kraj	65,493,013 bp
Obrazac RNK izražavanja
	; ;
	More reference expression data
Genska ontologija
Molecular function	• nucleotide binding; • GO:0001948, GO:0016582 везивање за протеине плазме; • GO:0010577 enzyme activator activity; • ATP binding; • DNA clamp loader activity; • DNA binding; • sequence-specific DNA binding; • double-stranded DNA binding; • protein domain specific binding; • DNA clamp unloader activity;
Cellular component	• Нуклеоплазма; • extracellular exosome; • Replikacioni faktor C; • једро; • Једарце; • цитоплазма; • Elg1 RFC-like complex; • GO:0009327 макромолекуларни комплекс;
Biological process	• DNA-dependent DNA replication; • nucleotide-excision repair, DNA gap filling; • GO:0009373 regulation of transcription, DNA-templated; • telomere maintenance via telomerase; • error-free translesion synthesis; • transcription, DNA-templated; • error-prone translesion synthesis; • репликација ДНК; • translesion synthesis; • transcription-coupled nucleotide-excision repair; • nucleotide-excision repair, DNA incision; • GO:0100026 поправка ДНК; • nucleotide-excision repair, DNA incision, 5'-to lesion; • GO:0048554 positive regulation of catalytic activity; • GO:1901227 negative regulation of transcription by RNA polymerase II; • GO:0045996 negative regulation of transcription, DNA-templated; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • telomere maintenance via semi-conservative replication; • DNA clamp unloading;
	Sources:Amigo / QuickGO
Ortolozi
	5981
	19687
	ENSG00000035928
	ENSMUSG00000029191
	P35251
	P35601
	NM_001204747; NM_002913; NM_001363495; NM_001363496
	NM_011258; NM_001347357; NM_001347358
	NP_001191676; NP_002904; NP_001350424; NP_001350425
	NP_001334286; NP_001334287; NP_035388
	Wikidata
View/Edit Human	View/Edit Mouse

Replikacioni faktor C, podjednica 1 je protein koji je kod ljudi kodiran RFC1 genom.^[4]^[5]

Protein kodiran ovim genom je velika podjedinica replikacionog faktora C, koji je pomoćni protein DNK polimeraze sa pet podjedinica. Replikacioni faktor C je od DNK zavisna ATPaza koja je neophodna za eukariotsku DNK replikaciju i popravku. Protein deluje kao aktivator DNK polimeraza, putem vezivanja za 3' kraj prajmera, i promoviše koordiniranu sintezu oba lanca. On takođe doprinosi stabilnosti telomera.^[5]

Interakcije

RFC1 formira interakcije sa:

BRD4,^[6]
HDAC1,^[7]
PCNA,^[6]^[8]^[9]^[10]^[11]
RELA^[12] and
RFC3.^[13]^[14]^[15]

Reference

^ ^а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000029191 - Ensembl, May 2017
^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Luckow B, Bunz F, Stillman B, Lichter P, Schutz G (1994). „Cloning, expression, and chromosomal localization of the 140-kilodalton subunit of replication factor C from mice and humans”. Mol Cell Biol. 14 (3): 1626—34. PMC 358521 . PMID 8114700.
^ ^а ^б „Entrez Gene: RFC1 replication factor C (activator 1) 1, 145kDa”.
^ ^а ^б Maruyama T, Farina A, Dey A, Cheong J, Bermudez VP, Tamura T, Sciortino S, Shuman J, Hurwitz J, Ozato K (2002). „A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase”. Mol. Cell. Biol. 22 (18): 6509—20. PMC 135621 . PMID 12192049. doi:10.1128/mcb.22.18.6509-6520.2002.
^ Anderson LA, Perkins ND (2002). „The large subunit of replication factor C interacts with the histone deacetylase, HDAC1”. J. Biol. Chem. 277 (33): 29550—4. PMID 12045192. doi:10.1074/jbc.M200513200.
^ Fotedar R, Mossi R, Fitzgerald P, Rousselle T, Maga G, Brickner H, Messier H, Kasibhatla S, Hübscher U, Fotedar A (1996). „A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells”. EMBO J. 15 (16): 4423—33. PMC 452166 . PMID 8861969.
^ Mossi R, Jónsson ZO, Allen BL, Hardin SH, Hübscher U (1997). „Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen”. J. Biol. Chem. 272 (3): 1769—76. PMID 8999859. doi:10.1074/jbc.272.3.1769.
^ van der Kuip H, Carius B, Haque SJ, Williams BR, Huber C, Fischer T (1999). „The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins”. J. Mol. Med. 77 (4): 386—92. PMID 10353443. doi:10.1007/s001090050365.
^ Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. 277 (43): 40362—7. PMID 12171929. doi:10.1074/jbc.M206194200.
^ Anderson LA, Perkins ND (2003). „Regulation of RelA (p65) function by the large subunit of replication factor C”. Mol. Cell. Biol. 23 (2): 721—32. PMC 151544 . PMID 12509469. doi:10.1128/mcb.23.2.721-732.2003.
^ Ellison V, Stillman B (1998). „Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity”. J. Biol. Chem. 273 (10): 5979—87. PMID 9488738. doi:10.1074/jbc.273.10.5979.
^ Uhlmann F, Cai J, Flores-Rozas H, Dean FB, Finkelstein J, O'Donnell M, Hurwitz J (1996). „In vitro reconstitution of human replication factor C from its five subunits”. Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6521—6. PMC 39056 . PMID 8692848. doi:10.1073/pnas.93.13.6521.
^ Tomida J, Masuda Y, Hiroaki H, Ishikawa T, Song I, Tsurimoto T, Tateishi S, Shiomi T, Kamei Y, Kim J, Kamiya K, Vaziri C, Ohmori H, Todo T (2008). „DNA damage-induced ubiquitylation of RFC2 subunit of replication factor C complex”. J. Biol. Chem. 283 (14): 9071—9. PMC 2431014 . PMID 18245774. doi:10.1074/jbc.M709835200.

Literatura

Lu Y, Riegel AT (1994). „The human DNA-binding protein, PO-GA, is homologous to the large subunit of mouse replication factor C: regulation by alternate 3' processing of mRNA”. Gene. 145 (2): 261—5. PMID 7914507. doi:10.1016/0378-1119(94)90017-5.
Bunz F, Kobayashi R, Stillman B (1994). „cDNAs encoding the large subunit of human replication factor C”. Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11014—8. PMC 47912 . PMID 8248204. doi:10.1073/pnas.90.23.11014.
Lu Y, Zeft AS, Riegel AT (1993). „Cloning and expression of a novel human DNA binding protein, PO-GA”. Biochem. Biophys. Res. Commun. 193 (2): 779—86. PMID 8512577. doi:10.1006/bbrc.1993.1693.
Uhlmann F, Cai J, Flores-Rozas H, Dean FB, Finkelstein J, O'Donnell M, Hurwitz J (1996). „In vitro reconstitution of human replication factor C from its five subunits”. Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6521—6. PMC 39056 . PMID 8692848. doi:10.1073/pnas.93.13.6521.
Fotedar R, Mossi R, Fitzgerald P, Rousselle T, Maga G, Brickner H, Messier H, Kasibhatla S, Hübscher U, Fotedar A (1996). „A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells”. EMBO J. 15 (16): 4423—33. PMC 452166 . PMID 8861969.
Uchiumi F, Ohta T, Tanuma S (1997). „Replication factor C recognizes 5'-phosphate ends of telomeres”. Biochem. Biophys. Res. Commun. 229 (1): 310—5. PMID 8954124. doi:10.1006/bbrc.1996.1798.
Mossi R, Jónsson ZO, Allen BL, Hardin SH, Hübscher U (1997). „Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen”. J. Biol. Chem. 272 (3): 1769—76. PMID 8999859. doi:10.1074/jbc.272.3.1769.
Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM (1997). „The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme”. Mol. Cell. Biol. 17 (4): 1817—23. PMC 232028 . PMID 9121429.
Ubeda M, Habener JF (1997). „The large subunit of the DNA replication complex C (DSEB/RF-C140) cleaved and inactivated by caspase-3 (CPP32/YAMA) during Fas-induced apoptosis”. J. Biol. Chem. 272 (31): 19562—8. PMID 9235961. doi:10.1074/jbc.272.31.19562.
Rhéaume E, Cohen LY, Uhlmann F, Lazure C, Alam A, Hurwitz J, Sékaly RP, Denis F (1998). „The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis”. EMBO J. 16 (21): 6346—54. PMC 1170241 . PMID 9351817. doi:10.1093/emboj/16.21.6346.
Ellison V, Stillman B (1998). „Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity”. J. Biol. Chem. 273 (10): 5979—87. PMID 9488738. doi:10.1074/jbc.273.10.5979.
Coll JM, Hickey RJ, Cronkey EA, Jiang HY, Schnaper L, Lee MY, Uitto L, Syvaoja JE, Malkas LH (1998). „Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome”. Oncol. Res. 9 (11–12): 629—39. PMID 9563011.
Allen BL, Uhlmann F, Gaur LK, Mulder BA, Posey KL, Jones LB, Hardin SH (1998). „DNA recognition properties of the N-terminal DNA binding domain within the large subunit of replication factor C”. Nucleic Acids Res. 26 (17): 3877—82. PMC 147807 . PMID 9705493. doi:10.1093/nar/26.17.3877.
van der Kuip H, Carius B, Haque SJ, Williams BR, Huber C, Fischer T (1999). „The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins”. J. Mol. Med. 77 (4): 386—92. PMID 10353443. doi:10.1007/s001090050365.
Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J (2000). „BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures”. Genes Dev. 14 (8): 927—39. PMC 316544 . PMID 10783165. doi:10.1101/gad.14.8.927.
Yazdi PT, Wang Y, Zhao S, Patel N, Lee EY, Qin J (2002). „SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint”. Genes Dev. 16 (5): 571—82. PMC 155356 . PMID 11877377. doi:10.1101/gad.970702.
Anderson LA, Perkins ND (2002). „The large subunit of replication factor C interacts with the histone deacetylase, HDAC1”. J. Biol. Chem. 277 (33): 29550—4. PMID 12045192. doi:10.1074/jbc.M200513200.
Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. 277 (43): 40362—7. PMID 12171929. doi:10.1074/jbc.M206194200.
Maruyama T, Farina A, Dey A, Cheong J, Bermudez VP, Tamura T, Sciortino S, Shuman J, Hurwitz J, Ozato K (2002). „A Mammalian Bromodomain Protein, Brd4, Interacts with Replication Factor C and Inhibits Progression to S Phase”. Mol. Cell. Biol. 22 (18): 6509—20. PMC 135621 . PMID 12192049. doi:10.1128/MCB.22.18.6509-6520.2002.