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Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Protostadienolna sintaza
Protostadienolna sintaza
Identifikatori
EC broj	5.4.99.32
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Protostadienolna sintaza (EC 5.4.99.32, PdsA, (S)-2,3-epoksiskvalen mutaza (ciklizacija, formira (17Z)-protosta-17(20),24-dien-3beta-ol)) je enzim sa sistematskim imenom (3S)-2,3-epoksi-2,3-dihidroskvalen mutaza (ciklizacija, formira (17Z)-protosta-17(20),24-dien-3beta-ol).^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

(3S)-2,3-epoksi-2,3-dihidroskvalen

\rightleftharpoons

(17Z)-protosta-17(20),24-dien-3beta-ol

(17Z)-Protosta-17(20),24-dien-3beta-ol je prekurzor steroidalnog antibiotika helvolinske kiseline.

Reference

^ Lodeiro, S., Xiong, Q., Wilson, W.K., Ivanova, Y., Smith, M.L., May, G.S. and Matsuda, S.P. (2009). „Protostadienol biosynthesis and metabolism in the pathogenic fungus Aspergillus fumigatus”. Org. Lett. 11: 1241—1244. PMID 19216560.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Protostadienol+synthase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Lodeiro, S., Xiong, Q., Wilson, W.K., Ivanova, Y., Smith, M.L., May, G.S. and Matsuda, S.P. (2009). „Protostadienol biosynthesis and metabolism in the pathogenic fungus Aspergillus fumigatus”. Org. Lett. 11: 1241—1244. PMID 19216560.

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