PROFILPELAJAR.COM

Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Prostaglandin-I sintaza
Prostaglandin-I sintaza
Identifikatori
EC broj	5.3.99.4
CAS broj	65802-86-0
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Prostaglandin-I sintaza (EC 5.3.99.4, prostaciklinska sintaza, prostaciklinska sintetaza, prostagladinska I2 sintetaza, PGI2 sintaza, PGI2 sintetaza) je enzim sa sistematskim imenom (5Z,13E)-(15S)-9alfa,11alfa-epidioksi-15-hidroksiprosta-5,13-dienoat 6-izomeraza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

(5Z,13E)-(15S)-9alfa,11alfa-epidioksi-15-hidroksiprosta-5,13-dienoat

\rightleftharpoons

(5Z,13E)-(15S)-6,9alfa-epoksi-11alfa,15-dihidroksiprosta-5,13-dienoat

Ovaj enzim konvertuje prostaglandin H2 u prostaglandin I2 (prostaciklin).

Reference

^ DeWitt, D.L. & Smith, W.L. (1983). „Purification of prostacyclin synthase from bovine aorta by immunoaffinity chromatography. Evidence that the enzyme is a hemoprotein”. J. Biol. Chem. 258: 3285—3293. PMID 6338016.
^ Ullrich, V., Castle, L. and Weber, P. (1981). „Spectral evidence for the cytochrome P₄₅₀ nature of prostacyclin synthetase”. Biochem. Pharmacol. 30: 2033—2036. PMID 7023490.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Prostaglandin-I+synthase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] DeWitt, D.L. & Smith, W.L. (1983). „Purification of prostacyclin synthase from bovine aorta by immunoaffinity chromatography. Evidence that the enzyme is a hemoprotein”. J. Biol. Chem. 258: 3285—3293. PMID 6338016.

[2] Ullrich, V., Castle, L. and Weber, P. (1981). „Spectral evidence for the cytochrome P₄₅₀ nature of prostacyclin synthetase”. Biochem. Pharmacol. 30: 2033—2036. PMID 7023490.

[1]

[2]