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Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Piruvat sintaza
Piruvat sintaza
Identifikatori
EC broj	1.2.7.1
CAS broj	9082-51-3
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Piruvat sintaza (EC 1.2.7.1, piruvatna oksidoreduktaza, piruvatna sintetaza, piruvat:feredoksin oksidoreduktaza, piruvinska-feredoksinska oksidoreduktaza) je enzim sa sistematskim imenom piruvat:feredoksin 2-oksidoreduktaza (KoA-acetilacija).^[1]^[2]^[3]^[4]^[5] Ovaj enzim katalizuje sledeću hemijsku reakciju

piruvat + KoA + 2 oksidovani feredoksin

\rightleftharpoons

acetil-KoA + CO₂ + 2 redukovani feredoksin + 2 H⁺

Ovaj enzim sadrži tiamin difosfat i [4Fe-4S] klastere. On je jedan od četiri 2-oksokiselinske oksidoreduktaze koji se razlikujuj po njihovoj sposobnosti da oksidativno dekarboksiluju različite 2-oksokiseline i formiraju KoA derivate, cf. EC 1.2.7.3, 2-oksoglutarat sintaza, EC 1.2.7.7, 3-metil-2-oksobutanoat dehidrogenaza (feredoksin) i EC 1.2.7.8, indolpiruvat feredoksin oksidoreduktaza.

Reference

^ Evans, M.C.W. & Buchanan, B.B. (1965). „Photoreduction of ferredoxin and its use in carbon dioxide fixation by a subcellular system from a photosynthetic bacterium”. Proc. Natl. Acad. Sci. USA. 53: 1420—1425. PMID 5217644.
^ Gehring, U. & Arnon, D.I. (1972). „Purification and properties of α-ketoglutarate synthase from a photosynthetic bacterium”. J. Biol. Chem. 247: 6963—6969. PMID 4628267.
^ Uyeda, K. & Rabinowitz, J.C. (1971). „Pyruvate-ferredoxin oxidoreductase. 3. Purification and properties of the enzyme”. J. Biol. Chem. 246: 3111—3119. PMID 5574389.
^ Uyeda, K. & Rabinowitz, J.C. (1971). „Pyruvate-ferredoxin oxidoreductase. IV. Studies on the reaction mechanism”. J. Biol. Chem. 246: 3120—3125. PMID 4324891.
^ Charon, M.-H., Volbeda, A., Chabriere, E., Pieulle, L. and Fontecilla-Camps, J.C. (1999). „Structure and electron transfer mechanism of pyruvate:ferredoxin oxidoreductase”. Curr. Opin. Struct. Biol. 9: 663—669. PMID 10607667.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Pyruvate+synthase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Evans, M.C.W. & Buchanan, B.B. (1965). „Photoreduction of ferredoxin and its use in carbon dioxide fixation by a subcellular system from a photosynthetic bacterium”. Proc. Natl. Acad. Sci. USA. 53: 1420—1425. PMID 5217644.

[2] Gehring, U. & Arnon, D.I. (1972). „Purification and properties of α-ketoglutarate synthase from a photosynthetic bacterium”. J. Biol. Chem. 247: 6963—6969. PMID 4628267.

[3] Uyeda, K. & Rabinowitz, J.C. (1971). „Pyruvate-ferredoxin oxidoreductase. 3. Purification and properties of the enzyme”. J. Biol. Chem. 246: 3111—3119. PMID 5574389.

[4] Uyeda, K. & Rabinowitz, J.C. (1971). „Pyruvate-ferredoxin oxidoreductase. IV. Studies on the reaction mechanism”. J. Biol. Chem. 246: 3120—3125. PMID 4324891.

[5] Charon, M.-H., Volbeda, A., Chabriere, E., Pieulle, L. and Fontecilla-Camps, J.C. (1999). „Structure and electron transfer mechanism of pyruvate:ferredoxin oxidoreductase”. Curr. Opin. Struct. Biol. 9: 663—669. PMID 10607667.

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