Peptidilprolilna izomeraza

Peptidilprolilna izomeraza
Identifikatori
EC broj5.2.1.8
CAS broj95076-93-0
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Peptidilprolilna izomeraza (EC 5.2.1.8, PPIaza, ciklofilin, peptid vezana izomeraza, peptidilna-prolil cis-trans izomeraza) je enzim sa sistematskim imenom peptidilprolin cis-trans-izomeraza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju

peptidilnaprolin (omega = 180) peptidilnaprolin (omega = 0)

Prvi pronađeni tip ovog enzima je proteinski ciklofilin, koji vezuje imunosupresant ciklosporin A. Postoje druge distinktne familije. Među njima su FK-506 vezujući proteini (FKBP).

Reference

  1. ^ Fischer, G. & Bang, H. (1985). „The refolding of urea-denatured ribonuclease A is catalyzed by peptidyl-prolyl cis-trans isomerase”. Biochim. Biophys. Acta. 828: 39—42. PMID 3882150. 
  2. ^ Fischer, G., Bang, H. and Mech, C. (1984). „[Determination of enzymatic catalysis for the cis-trans-isomerization of peptide binding in proline-containing peptides]”. Biomed. Biochim. Acta. 43: 1101—1111. PMID 6395866. 
  3. ^ Fischer, G., Wittmann-Liebold, B., Lang, K., Kiefhaber, T. and Schmid, F.X. (1989). „Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins”. Nature. 337: 476—478. PMID 2492638. 
  4. ^ Takahashi, N., Hayano, T. and Suzuki, M. (1989). „Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin”. Nature. 337: 473—475. PMID 2644542. 
  5. ^ Hennig, L., Christner, C., Kipping, M., Schelbert, B., Rucknagel, K.P., Grabley, S., Kullertz, G. and Fischer, G. (1998). „Selective inactivation of parvulin-like peptidyl-prolyl cis/trans isomerases by juglone”. Biochemistry. 37: 5953—5960. PMID 9558330. 
  6. ^ Fischer, G. (1994). „Peptidyl-prolyl cis/trans isomerases and their effectors”. Angew. Chem. Int. Ed. Engl. 33: 1415—1436. 
  7. ^ Harrison, R.K. & Stein, R.L. (1990). „Substrate specificities of the peptidyl prolyl cis-trans isomerase activities of cyclophilin and FK-506 binding protein: evidence for the existence of a family of distinct enzymes”. Biochemistry. 29: 3813—3816. PMID 1693856. 
  8. ^ Eisenmesser, E.Z., Bosco, D.A., Akke, M. and Kern, D. (2002). „Enzyme dynamics during catalysis”. Science. 295: 1520—1523. PMID 11859194. 

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