Papalizin 1

Papalizin 1
Identifikatori
EC broj3.4.24.79
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Papalizin 1 (EC 3.4.24.79, proteaza insulinu-sličnog faktora vezujućeg proteina-4) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju

Razlaganje Met135-Lys veze u insulinu-sličnom faktor rasta vezujućem proteinu (IGFBP4), i Ser143-Lys veze u IGFBP5

Ovaj enzip pripada peptidaznoj familiji M43.

Reference

  1. ^ Lawrence, J.B., Oxvig, C., Overgaard, M.T., Sottrup-Jensen, L., Gleich, G.J. (1999). „, Hays L.G., Yates, J.R. 3rd, and Conover, C.A. The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A”. Proc. Natl. Acad. Sci. USA. 96: 3149—3153. PMID 10077652. 
  2. ^ Chen, B.K., Overgaard, M.T., Bale, L.K., Resch, Z.T., Christiansen, M., Oxvig, C. and Conover, C.A. (2002). „Molecular regulation of the IGF-binding protein-4 protease system in human fibroblasts: identification of a novel inducible inhibitor”. Endocrinology. 143: 1199—1205. PMID 11897673. 

Literatura

Spoljašnje veze

  • Pappalysin-1 на US National Library of Medicine Medical Subject Headings (MeSH)