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Palmitoil(protein) hidrolaza
Palmitoil(protein) hidrolaza
Identifikatori
EC broj	3.1.2.22
CAS broj	150605-49-5
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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Palmitoil(protein) hidrolaza (EC 3.1.2.22, palmitoil-protein tioesteraza, palmitoil-(protein) hidrolaza) je enzim sa sistematskim imenom palmitoil(protein) hidrolaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

palmitoil[protein] + H₂O

\rightleftharpoons

palmitat + protein

Ovaj enzim je specifičan za dugolančane tioestre masnih kiselina.

Reference

^ Camp, L.A., Hofmann, S.L. (1995). „Assay and isolation of palmitoyl-protein thioesterase from bovine brain using palmitoylated H-Ras as substrate”. Methods Enzymol. 250: 336—347. PMID 7651163.
^ Schriner, J.E., Yi, W., Hofmann, S.L. (1996). „cDNA and genomic cloning of human palmitoyl-protein thioesterase (PPT), the enzyme defective in infantile neuronal ceroid lipofuscinosis”. Genomics,. 34: 317—322. PMID 8786130.
^ Verkruyse, L.A., Hofmann, S.L. (1996). „Lysosomal targeting of palmitoyl-protein thioesterase”. J. Biol. Chem. 271: 15831—15836. PMID 8663305.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Palmitoyl(protein)+hydrolase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Camp, L.A., Hofmann, S.L. (1995). „Assay and isolation of palmitoyl-protein thioesterase from bovine brain using palmitoylated H-Ras as substrate”. Methods Enzymol. 250: 336—347. PMID 7651163.

[2] Schriner, J.E., Yi, W., Hofmann, S.L. (1996). „cDNA and genomic cloning of human palmitoyl-protein thioesterase (PPT), the enzyme defective in infantile neuronal ceroid lipofuscinosis”. Genomics,. 34: 317—322. PMID 8786130.

[3] Verkruyse, L.A., Hofmann, S.L. (1996). „Lysosomal targeting of palmitoyl-protein thioesterase”. J. Biol. Chem. 271: 15831—15836. PMID 8663305.

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