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Oktanoil-(GcvH):protein N-oktanoiltransferaza
Oktanoil-(GcvH):protein N-oktanoiltransferaza
Identifikatori
EC broj	2.3.1.204
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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PMC	članci
PubMed	članci
NCBI	proteini

Oktanoil-(GcvH):protein N-oktanoiltransferaza (EC 2.3.1.204, LIPL, oktanoil-(GcvH):E2 amidotransferaza, YWFL (gen)) je enzim sa sistematskim imenom (sistem H odvajanja glicina)-N⁶-oktanoil-L-lizin:(lipoil-nosilac protein)-N⁶-L-lizin oktanoiltransferaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

[sistem H odvajanja glicina]-N⁶-oktanoil-L-lizin + [lipoil-nosilac protein]

\rightleftharpoons

sistem H odvajanja glicina + [lipoil-nosilac protein]-N⁶-oktanoil-L-lizin

Kod bakterije Bacillus subtilis ovaj enzim katalizuje amidotransfer oktanoilne grupe sa [sistem H za odvajanje glicina]-N⁶-oktanoil-L-lizina (i.e. oktanoil-GcvH) na E2 podjednicu (dihidrolipoamid acetiltransferazu) piruvatne dehidrogenaze.

Reference

^ Christensen, Q.H., Martin, N., Mansilla, M.C., de Mendoza, D. and Cronan, J.E. (2011). „A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis”. Mol. Microbiol. 80: 350—363. PMID 21338421.
^ Martin, N., Christensen, Q.H., Mansilla, M.C., Cronan, J.E. and de Mendoza, D. (2011). „A novel two-gene requirement for the octanoyltransfer reaction of Bacillus subtilis lipoic acid biosynthesis”. Mol. Microbiol. 80: 335—349. PMID 21338420.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Octanoyl-(GcvH):protein+N-octanoyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Christensen, Q.H., Martin, N., Mansilla, M.C., de Mendoza, D. and Cronan, J.E. (2011). „A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis”. Mol. Microbiol. 80: 350—363. PMID 21338421.

[2] Martin, N., Christensen, Q.H., Mansilla, M.C., Cronan, J.E. and de Mendoza, D. (2011). „A novel two-gene requirement for the octanoyltransfer reaction of Bacillus subtilis lipoic acid biosynthesis”. Mol. Microbiol. 80: 335—349. PMID 21338420.

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