Oksazepam

Oksazepam
Klinički podaci
Prodajno imeAdumbran, Ansioxacepam, Anxiolit, Aplakil
Drugs.comMonografija
Način primeneOralno
Farmakokinetički podaci
Poluvreme eliminacije8,2 h
Identifikatori
CAS broj604-75-1 ДаY
ATC kodN05BA04 (WHO)
PubChemCID 4616
DrugBankDB00842 ДаY
ChemSpider4455 ДаY
KEGGC07359 ДаY
ChEBICHEBI:7823 ДаY
ChEMBLCHEMBL568 ДаY
Hemijski podaci
FormulaC15H11ClN2O2
Molarna masa286,713
  • OC1N=C(C2=CC=CC=C2)C2=C(NC1=O)C=CC(Cl)=C2
  • InChI=1S/C15H11ClN2O2/c16-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)18-15(20)14(19)17-12/h1-8,15,20H,(H,17,19) ДаY
  • Key:ADIMAYPTOBDMTL-UHFFFAOYSA-N ДаY
Fizički podaci
Tačka topljenja205—206 °C (401—403 °F)

Oksazepam je organsko jedinjenje, koje sadrži 15 atoma ugljenika i ima molekulsku masu od 286,713 Da.[1][2][3][4][5][6][7][8]

Osobine

Osobina Vrednost
Broj akceptora vodonika 3
Broj donora vodonika 2
Broj rotacionih veza 1
Particioni koeficijent[9] (ALogP) 2,8
Rastvorljivost[10] (logS, log(mol/L)) -4,7
Polarna površina[11] (PSA, Å2) 61,7

Reference

  1. ^ Peppers MP: Benzodiazepines for alcohol withdrawal in the elderly and in patients with liver disease. Pharmacotherapy. 1996 Jan-Feb;16(1):49-57. PMID 8700792
  2. ^ Skerritt JH, Johnston GA: Enhancement of GABA binding by benzodiazepines and related anxiolytics. Eur J Pharmacol. 1983 May 6;89(3-4):193-8. PMID 6135616
  3. ^ Oelschlager H: [Chemical and pharmacologic aspects of benzodiazepines] Schweiz Rundsch Med Prax. 1989 Jul 4;78(27-28):766-72. PMID 2570451
  4. ^ Christensen P, Lolk A, Gram LF, Kragh-Sorensen P: Benzodiazepine-induced sedation and cortisol suppression. A placebo-controlled comparison of oxazepam and nitrazepam in healthy male volunteers. Psychopharmacology (Berl). 1992;106(4):511-6. PMID 1349754
  5. ^ Olive G, Dreux C: [Pharmacologic bases of use of benzodiazepines in pereinatal medicine] Arch Fr Pediatr. 1977 Jan;34(1):74-89. PMID 851373
  6. ^ Altamura AC, Moliterno D, Paletta S, Maffini M, Mauri MC, Bareggi S: Understanding the pharmacokinetics of anxiolytic drugs. Expert Opin Drug Metab Toxicol. 2013 Apr;9(4):423-40. doi: 10.1517/17425255.2013.759209. Epub 2013 Jan 21. PMID 23330992
  7. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 Слободан приступ. PMID 21059682. doi:10.1093/nar/gkq1126.  уреди
  8. ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 Слободан приступ. PMID 18048412. doi:10.1093/nar/gkm958.  уреди
  9. ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 
  10. ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.  уреди
  11. ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.  уреди

Literatura

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