On je najbolje poznat po razvoju koncepta DNK nanotehnologije početkom ranih 1980-tih.[1][4][5] Simanova laboratorija je objavila sintezu prvog trodimenzionog nanoobjekta, kocke napravljene od DNK 1991.[6]
Pinheiro, Andre V.; Han, Dongran; Shih, William M.; Yan, Hao (2011). „Challenges and opportunities for structural DNA nanotechnology”. Nature Nanotechnology. 6 (12): 763—772. PMID22056726. doi:10.1038/nnano.2011.187.
Chen, Junghuei; Seeman, Nadrian C (1991). „Synthesis from DNA of a molecule with the connectivity of a cube”. Nature. 350 (6319): 631. PMID2017259. doi:10.1038/350631a0.
Winfree, Erik; Liu, Furong; Wenzler, Lisa A. & Seeman, Nadrian C. (1998). „Design and self-assembly of two-dimensional DNA crystals”. Nature. 394 (6693): 529—544. ISSN0028-0836. PMID9707114. doi:10.1038/28998.
Mao, Chengde; Sun, Weiqiong; Shen, Zhiyong & Seeman, Nadrian C. (1999). „A DNA Nanomechanical Device Based on the B-Z Transition”. Nature. 397 (6715): 144—146. ISSN0028-0836. PMID9923675. doi:10.1038/16437.