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NADH dehidrogenaza (ubihinon)
NADH dehidrogenaza (ubihinon)
Identifikatori
EC broj	1.6.5.3
CAS broj	9028-04-0
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

NADH dehidrogenaza (ubihinon) (EC 1.6.5.3, ubihinonska reduktaza, tip 1 dehidrogenaza, kompleks 1 dehidrogenaza, koenzim Q reduktaza, kompleks I (lanac transporta elektrona), kompleks I (mitohondrijalni elektronsk transport), kompleks I (NADH:Q1 oksidoreduktaza), dihidronikotinamid adenin dinukleotid-koenzim Q reduktaza, DPNH-koenzim Q reduktaza, DPNH-ubihinon reduktaza, mitohondrijalni elektronski transportni kompleks 1, mitohondrijalni elektronski transportni kompleks I, NADH koenzim Q1 reduktaza, NADH-koenzim Q oksidoreduktaza, NADH-koenzim Q reduktaza, NADH-CoQ oksidoreduktaza, NADH-CoQ reduktaza, NADH-ubihinonska reduktaza, NADH-ubihinonska oksidoreduktaza, NADH-ubihinon-1 reduktaza, redukovani nikotinamid adenin dinukleotid-koenzim Q reduktaza, NADH:ubihinon oksidoreduktazni kompleks, NADH-Q6 oksidoreduktaza, kompleks transfera elektrona I, NADH2 dehidrogenaza (ubihinon)) je enzim sa sistematskim imenom NADH:ubihinon oksidoreduktaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

NADH + ubihinon + 5 H⁺in

\rightleftharpoons

NAD⁺ + ubihinol + 4 H⁺out

Ovaj enzim je flavoprotein koji sadrži gvožđe-sumporne klustere.

Reference

^ Hatefi, Y., Ragan, C.I. and Galante, Y.M. (1985). „The enzymes and the enzyme complexes of the mitochondrial oxidative phosphorylation system”. Ур.: Martonosi, A. The Enzymes of Biological Membranes. 4 (2nd изд.). New York: Plenum Press. стр. 1—70.
^ Herter, S.M., Kortluke, C.M. and Drews, G. (1998). „Complex I of Rhodobacter capsulatus and its role in reverted electron transport”. Arch. Microbiol. 169: 98—105. PMID 9446680.
^ Hunte, C., Zickermann, V. and Brandt, U. (2010). „Functional modules and structural basis of conformational coupling in mitochondrial complex I”. Science. 329: 448—451. PMID 20595580.
^ Efremov, R.G., Baradaran, R. and Sazanov, L.A. (2010). „The architecture of respiratory complex I”. Nature. 465: 441—445. PMID 20505720.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

NADH+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Hatefi, Y., Ragan, C.I. and Galante, Y.M. (1985). „The enzymes and the enzyme complexes of the mitochondrial oxidative phosphorylation system”. Ур.: Martonosi, A. The Enzymes of Biological Membranes. 4 (2nd изд.). New York: Plenum Press. стр. 1—70.

[2] Herter, S.M., Kortluke, C.M. and Drews, G. (1998). „Complex I of Rhodobacter capsulatus and its role in reverted electron transport”. Arch. Microbiol. 169: 98—105. PMID 9446680.

[3] Hunte, C., Zickermann, V. and Brandt, U. (2010). „Functional modules and structural basis of conformational coupling in mitochondrial complex I”. Science. 329: 448—451. PMID 20595580.

[4] Efremov, R.G., Baradaran, R. and Sazanov, L.A. (2010). „The architecture of respiratory complex I”. Nature. 465: 441—445. PMID 20505720.

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