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N-metilkoklaurin 3'-monooksigenaza
N-metilkoklaurin 3'-monooksigenaza
Identifikatori
EC broj	1.14.13.71
CAS broj	202420-37-9
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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PMC	članci
PubMed	članci
NCBI	proteini

N-metilkoklaurin 3'-monooksigenaza (EC 1.14.13.71, N-metilkoklaurinska 3'-hidroksilaza) je enzim sa sistematskim imenom (S)-N-metilkoklaurin,NADPH:kiseonik oksidoreduktaza (3'-hidroksilacija).^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

(S)-N-metilkoklaurin + NADPH + H⁺ + O₂

\rightleftharpoons

(S)-3'-hidroksi-N-metilkoklaurin + NADP⁺ + H₂O

Ovaj enzim je hem-tiolatni protein (P-450) koji učestvuje u sintezi benzilizohinolinskih alkaloida kod viših biljki.

Reference

^ Pauli, H.H. & Kutchan, T.M. (1998). „Molecular cloning and functional heterologous expression of two alleles encoding (S)-N-methylcoclaurine 3′-hydroxylase (CYP80B1), a new methyl jasmonate-inducible cytochrome P-450-dependent mono-oxygenase of benzylisoquinoline alkaloid biosynthesis”. Plant J. 13: 793—801. PMID 9681018.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

N-methylcoclaurine+3'-monooxygenase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Pauli, H.H. & Kutchan, T.M. (1998). „Molecular cloning and functional heterologous expression of two alleles encoding (S)-N-methylcoclaurine 3′-hydroxylase (CYP80B1), a new methyl jasmonate-inducible cytochrome P-450-dependent mono-oxygenase of benzylisoquinoline alkaloid biosynthesis”. Plant J. 13: 793—801. PMID 9681018.

[1]