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N-metil-2-oksoglutaramatna hidrolaza
N-metil-2-oksoglutaramatna hidrolaza
Identifikatori
EC broj	3.5.1.36
CAS broj	9073-53-4
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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N-metil-2-oksoglutaramatna hidrolaza (EC 3.5.1.36, 5-hidroksi-N-metilpiroglutamatna sintaza) je enzim sa sistematskim imenom N-metil-2-oksoglutaramat metilamidohidrolaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

N-metil-2-oksoglutaramat + H₂O

\rightleftharpoons

2-oksoglutarat + metilamin

U reverznoj reakciji se produkt ciklizuje neenzimitski do 2-hidroksi-N-metil-5-oksoprolina.

Reference

^ Hersh, L.B. (1970). „5-Hydroxy-N-methylpyroglutamate synthetase. Purification and mechanism of action”. J. Biol. Chem. 245: 3526—3535. PMID 5470822.
^ Hersh, L.B., Tsai, L. and Stadtman, E.R. (1969). „The enzymatic synthesis of 5-hydroxy-N-methylpyroglutamic acid”. J. Biol. Chem. 244: 4677—4683. PMID 5808511.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

N-methyl-2-oxoglutaramate+hydrolase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Hersh, L.B. (1970). „5-Hydroxy-N-methylpyroglutamate synthetase. Purification and mechanism of action”. J. Biol. Chem. 245: 3526—3535. PMID 5470822.

[2] Hersh, L.B., Tsai, L. and Stadtman, E.R. (1969). „The enzymatic synthesis of 5-hydroxy-N-methylpyroglutamic acid”. J. Biol. Chem. 244: 4677—4683. PMID 5808511.

[1]

[2]