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N-malonilurejna hidrolaza
N-malonilurejna hidrolaza
Identifikatori
EC broj	3.5.1.95
CAS broj	368888-22-6
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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N-malonilurejna hidrolaza (EC 3.5.1.95, ureidomalonaza) je enzim sa sistematskim imenom 3-okso-3-ureidopropanoat amidohidrolaza (formira ureju i malonat).^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

3-okso-3-ureidopropanoat + H₂O

\rightleftharpoons

malonat + ureja

Ovaj enzim formira deo oksidativnog puta pirimidinske degradacije u pojedinim mikroorganizmima.

Reference

^ Soong, C.L., Ogawa, J. and Shimizu, S. (2001). „Novel amidohydrolytic reactions in oxidative pyrimidine metabolism: analysis of the barbiturase reaction and discovery of a novel enzyme, ureidomalonase”. Biochem. Biophys. Res. Commun. 286: 222—226. PMID 11485332.
^ Soong, C.L., Ogawa, J., Sakuradani, E. and Shimizu, S. (2002). „Barbiturase, a novel zinc-containing amidohydrolase involved in oxidative pyrimidine metabolism”. J. Biol. Chem. 277: 7051—7058. PMID 11748240.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

N-malonylurea+hydrolase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Soong, C.L., Ogawa, J. and Shimizu, S. (2001). „Novel amidohydrolytic reactions in oxidative pyrimidine metabolism: analysis of the barbiturase reaction and discovery of a novel enzyme, ureidomalonase”. Biochem. Biophys. Res. Commun. 286: 222—226. PMID 11485332.

[2] Soong, C.L., Ogawa, J., Sakuradani, E. and Shimizu, S. (2002). „Barbiturase, a novel zinc-containing amidohydrolase involved in oxidative pyrimidine metabolism”. J. Biol. Chem. 277: 7051—7058. PMID 11748240.

[1]

[2]