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N-acetilglukozaminilfosfatidillinozitolna deacetilaza
N-acetilglukozaminilfosfatidillinozitolna deacetilaza
Identifikatori
EC broj	3.5.1.89
CAS broj	122191-30-4
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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PMC	članci
PubMed	članci
NCBI	proteini

N-acetilglukozaminilfosfatidillinozitolna deacetilaza (EC 3.5.1.89, N-acetil-D-glukozaminilfosfatidilinozitolna acetilhidrolaza, N-acetilglukozaminilfosfatidilinozitolna de-N-acetilaza, GlcNAc-PI de-N-acetilaza, GlcNAc-PI deacetilaza, acetilglukozaminilfosfatidilinozitolna deacetilaza) je enzim sa sistematskim imenom 6-(N-acetil-alfa-D-glukozaminil)-1-fosfatidil-1D-mio-inozitol acetilhidrolaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

6-(N-acetil-alfa-D-glukozaminil)-1-fosfatidil-1D-mio-inozitol + H₂O

\rightleftharpoons

6-(alfa-D-glukozaminil)-1-fosfatidil-1D-mio-inozitol + acetat

Ovaj enzim učestvuje u drugom koraku glikozilfosfatidilinozitol (GPI) formiranja kod eukariota.

Reference

^ Doering, T.L., Masteron, W.J., Englund, P.T. and Hart, G.W. (1989). „Biosynthesis of the glycosyl phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein. Origin of the non-acetylated glucosamine”. J. Biol. Chem. 264: 11168—11173. PMID 2525555.
^ Nakamura, N., Inoue, N., Watanabe, R., Takahashi, M., Takeda, J., Stevens, V.L. and Kinoshita, T. (1997). „Expression cloning of PIG-L, a candidate N-acetylglucosaminyl-phosphatidylinositol deacetylase”. J. Biol. Chem. 272: 15834—15840. PMID 9188481.
^ Watanabe, R., Ohishi, K., Maeda, Y., Nakamura, N. and Kinoshita, T. (1999). „Mammalian PIG-L and its yeast homologue Gpi12p are N-acetylglucosaminylphosphatidylinositol de-N-acetylases essential in glycosylphosphatidylinositol biosynthesis”. Biochem. J. 339: 185—192. PMID 10085243.
^ Smith, T.K, Crossman, A., Borissow, C.N., Paterson, M.J., Dix, A., Brimacombe, J.S. and Ferguson, M.A.J. (2001). „Specificity of GlcNAc-PI de-N-acetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors”. EMBO J. 20: 3322—3332. PMID 11432820.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

N-acetylglucosaminylphosphatidylinositol+deacetylase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Doering, T.L., Masteron, W.J., Englund, P.T. and Hart, G.W. (1989). „Biosynthesis of the glycosyl phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein. Origin of the non-acetylated glucosamine”. J. Biol. Chem. 264: 11168—11173. PMID 2525555.

[2] Nakamura, N., Inoue, N., Watanabe, R., Takahashi, M., Takeda, J., Stevens, V.L. and Kinoshita, T. (1997). „Expression cloning of PIG-L, a candidate N-acetylglucosaminyl-phosphatidylinositol deacetylase”. J. Biol. Chem. 272: 15834—15840. PMID 9188481.

[3] Watanabe, R., Ohishi, K., Maeda, Y., Nakamura, N. and Kinoshita, T. (1999). „Mammalian PIG-L and its yeast homologue Gpi12p are N-acetylglucosaminylphosphatidylinositol de-N-acetylases essential in glycosylphosphatidylinositol biosynthesis”. Biochem. J. 339: 185—192. PMID 10085243.

[4] Smith, T.K, Crossman, A., Borissow, C.N., Paterson, M.J., Dix, A., Brimacombe, J.S. and Ferguson, M.A.J. (2001). „Specificity of GlcNAc-PI de-N-acetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors”. EMBO J. 20: 3322—3332. PMID 11432820.

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