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N-acetilglukozaminil-difosfo-dekaprenol L-ramnoziltransferaza
N-acetilglukozaminil-difosfo-dekaprenol L-ramnoziltransferaza
Identifikatori
EC broj	2.4.1.289
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
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N-acetilglukozaminil-difosfo-dekaprenol L-ramnoziltransferaza (EC 2.4.1.289, WbbL) je enzim sa sistematskim imenom dTDP-6-dezoksi-beta-L-manoza:N-acetil-alfa-D-glukozaminil-difosfo-trans,oktacis-dekaprenol 3-alfa-L-ramnoziltransferaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

dTDP-6-dezoksi-beta-L-manoza + N-acetil-alfa-D-glukozaminil-difosfo-trans,oktacis-dekaprenol

\rightleftharpoons

dTDP + alfa-L-ramnopiranozil-(1->3)-N-acetil-alfa-D-glukozaminil-difosfo-trans,oktacis-dekaprenol

Za dejstvo ovog enzima je neophodan Mn²⁺ ili Mg²⁺. On je izolovan iz Mycobakterija smegmatis i Mycobakterija tuberculosis.

Reference

^ Mills, J.A., Motichka, K., Jucker, M., Wu, H.P., Uhlik, B.C., Stern, R.J., Scherman, M.S., Vissa, V.D., Pan, F., Kundu, M., Ma, Y.F. and McNeil, M. (2004). „Inactivation of the mycobacterial rhamnosyltransferase, which is needed for the formation of the arabinogalactan-peptidoglycan linker, leads to irreversible loss of viability”. J. Biol. Chem. 279: 43540—43546. PMID 15294902.
^ Grzegorzewicz, A.E., Ma, Y., Jones, V., Crick, D., Liav, A. and McNeil, M.R. (2008). „Development of a microtitre plate-based assay for lipid-linked glycosyltransferase products using the mycobacterial cell wall rhamnosyltransferase WbbL”. Microbiology. 154: 3724—3730. PMID 19047740.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

N-acetylglucosaminyl-diphospho-decaprenol+L-rhamnosyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Mills, J.A., Motichka, K., Jucker, M., Wu, H.P., Uhlik, B.C., Stern, R.J., Scherman, M.S., Vissa, V.D., Pan, F., Kundu, M., Ma, Y.F. and McNeil, M. (2004). „Inactivation of the mycobacterial rhamnosyltransferase, which is needed for the formation of the arabinogalactan-peptidoglycan linker, leads to irreversible loss of viability”. J. Biol. Chem. 279: 43540—43546. PMID 15294902.

[2] Grzegorzewicz, A.E., Ma, Y., Jones, V., Crick, D., Liav, A. and McNeil, M.R. (2008). „Development of a microtitre plate-based assay for lipid-linked glycosyltransferase products using the mycobacterial cell wall rhamnosyltransferase WbbL”. Microbiology. 154: 3724—3730. PMID 19047740.

[1]

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