Malonatna dekarboksilaza zavisna od biotina

Biotin-zavisna malonatna dekarboksilaza
Identifikatori
EC broj4.1.1.89
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Malonatna dekarboksilaza zavisna od biotina (EC 4.1.1.89, malonat dekarboksilaza (sa biotinom), malonat dekarboksilaza) je enzim sa sistematskim imenom malonat karboksilijaza (biotin-zavisna).[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

malonat + H+ acetat + CO2

Pozanat su dva tipa malonatne dekarboksilaze. Oba su multienzimski kompleksi.

Reference

  1. ^ Hilbi, H., Dehning, I., Schink, B. and Dimroth, P. (1992). „Malonate decarboxylase of Malonomonas rubra, a novel type of biotin-containing acetyl enzyme”. Eur. J. Biochem. 207: 117—123. PMID 1628643. 
  2. ^ Hilbi, H. & Dimroth, P. (1994). „Purification and characterization of a cytoplasmic enzyme component of the Na+-activated malonate decarboxylase system of Malonomonas rubra: acetyl-S-acyl carrier protein: malonate acyl carrier protein-SH transferase”. Arch. Microbiol. 162: 48—56. PMID 18251085. 
  3. ^ Berg, M., Hilbi, H. and Dimroth, P. (1996). „The acyl carrier protein of malonate decarboxylase of Malonomonas rubra contains 2′-(5"-phosphoribosyl)-3′-dephosphocoenzyme A as a prosthetic group”. Biochemistry. 35: 4689—4696. PMID 8664258. 
  4. ^ Berg, M., Hilbi, H. and Dimroth, P. (1997). „Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function”. Eur. J. Biochem. 245: 103—115. PMID 9128730. 
  5. ^ Micklefield, J., Harris, K.J., Gröger, S., Mocek, U., Hilbi, H., Dimroth, P. and Floss, H.G. (1995). „Stereochemical course of malonate decarboxylase in Malonomonas rubra has biotin decarboxylation with retention”. J. Am. Chem. Soc. 117: 1153—1154. 
  6. ^ Kim, Y.S. (2002). „Malonate metabolism: biochemistry, molecular biology, physiology, and industrial application”. J. Biochem. Mol. Biol. 35: 443—451. PMID 12359084. 
  7. ^ Dimroth, P. & Hilbi, H. (1997). „Enzymic and genetic basis for bacterial growth on malonate”. Mol. Microbiol. 25: 3—10. PMID 11902724. 

Literatura

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