Malonatna dekarboksilaza nezavisna od biotina

Biotin-nezavisna malonatna dekarboksilaza
Identifikatori
EC broj4.1.1.88
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Biotin-nezavisna malonatna dekarboksilaza (EC 4.1.1.88, malonat dekarboksilaza (saout biotin), malonat dekarboksilaza, MDC) je enzim sa sistematskim imenom malonat karboksilijaza (biotin-nezavisna).[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju

malonat + H+ acetat + CO2

Pozanat su dva tipa malonatne dekarboksilaze. Oba su multienzimski kompleksi.

Reference

  1. ^ Schmid, M., Berg, M., Hilbi, H. and Dimroth, P. (1996). „Malonate decarboxylase of Klebsiella pneumoniae catalyses the turnover of acetyl and malonyl thioester residues on a coenzyme-A-like prosthetic group”. Eur. J. Biochem. 237: 221—228. PMID 8620876. 
  2. ^ Byun, H.S. & Kim, Y.S. (1997). „Subunit organization of bacterial malonate decarboxylases: the smallest δ subunit as an acyl-carrier protein”. J. Biochem. Mol. Biol. 30: 132—137. 
  3. ^ Hoenke, S., Schmid, M. and Dimroth, P. (1997). „Sequence of a gene cluster from Klebsiella pneumoniae encoding malonate decarboxylase and expression of the enzyme in Escherichia coli”. Eur. J. Biochem. 246: 530—538. PMID 9208947. 
  4. ^ Chohnan, S., Fujio, T., Takaki, T., Yonekura, M., Nishihara, H. and Takamura, Y. (1998). „Malonate decarboxylase of Pseudomonas putida is composed of five subunits”. FEMS Microbiol. Lett. 169: 37—43. PMID 9851033. 
  5. ^ Hoenke, S., Schmid, M. and Dimroth, P. (2000). „Identification of the active site of phosphoribosyl-dephospho-coenzyme A transferase and relationship of the enzyme to an ancient class of nucleotidyltransferases”. Biochemistry. 39: 13233—13240. PMID 11052676. 
  6. ^ Handa, S., Koo, J.H., Kim, Y.S. and Floss, H.G. (1999). „Stereochemical course of biotin-independent malonate decarboxylase catalysis”. Arch. Biochem. Biophys. 370: 93—96. PMID 10496981. 
  7. ^ Koo, J.H. & Kim, Y.S. (1999). „Functional evaluation of the genes involved in malonate decarboxylation by Acinetobacter calcoaceticus”. Eur. J. Biochem. 266: 683—690. PMID 10561613. 
  8. ^ Kim, Y.S. (2002). „Malonate metabolism: biochemistry, molecular biology, physiology, and industrial application”. J. Biochem. Mol. Biol. 35: 443—451. PMID 12359084. 
  9. ^ Dimroth, P. & Hilbi, H. (1997). „Enzymic and genetic basis for bacterial growth on malonate”. Mol. Microbiol. 25: 3—10. PMID 11902724. 

Literatura

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