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Litoholat 6-beta-hidroksilaza
Litoholat 6-beta-hidroksilaza
Identifikatori
EC broj	1.14.13.94
CAS broj	9075-83-6
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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NCBI	proteini

Litoholat 6-beta-hidroksilaza (EC 1.14.13.94, litoholatna 6beta-monooksigenaza, CYP3A10, 6beta-hidroksilaza, citohrom P450 3A10/lithocholic kiselina 6beta-hidroksilaza) je enzim sa sistematskim imenom litoholat,NADPH:kiseonik oksidoreduktaza (6beta-hidroksilacija).^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

litoholat + NADPH + H⁺ + O₂

\rightleftharpoons

6beta-hidroksilithoholat + NADP⁺ + H₂O

Ovaj enzim je hem-tiolatni protein (P-450). Ovaj enzim je 50-puta više izražen kod muških hrčaka.

Reference

^ Teixeira, J. & Gil, G. (1991). „Cloning, expression, and regulation of lithocholic acid 6β-hydroxylase”. J. Biol. Chem. 266: 21030—21036. PMID 1840595.
^ Chang, T.K., Teixeira, J., Gil, G. and Waxman, D.J. The lithocholic acid 6beta-hydroxylase cytochrome P-450, CYP (1993). „3A10, is an active catalyst of steroid-hormone 6β-hydroxylation”. Biochem. J. 291: 429—433. PMID 8484723.
^ Subramanian, A., Wang, J. and Gil, G. (1998). „STAT 5 and NF-Y are involved in expression and growth hormone-mediated sexually dimorphic regulation of cytochrome P₄₅₀ 3A10/lithocholic acid 6β-hydroxylase”. Nucleic Acids Res. 26: 2173—2178. PMID 9547277.
^ Russell, D.W. (2003). „The enzymes, regulation, and genetics of bile acid synthesis”. Annu. Rev. Biochem. 72: 137—174. PMID 12543708.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Lithocholate+6beta-hydroxylase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Teixeira, J. & Gil, G. (1991). „Cloning, expression, and regulation of lithocholic acid 6β-hydroxylase”. J. Biol. Chem. 266: 21030—21036. PMID 1840595.

[2] Chang, T.K., Teixeira, J., Gil, G. and Waxman, D.J. The lithocholic acid 6beta-hydroxylase cytochrome P-450, CYP (1993). „3A10, is an active catalyst of steroid-hormone 6β-hydroxylation”. Biochem. J. 291: 429—433. PMID 8484723.

[3] Subramanian, A., Wang, J. and Gil, G. (1998). „STAT 5 and NF-Y are involved in expression and growth hormone-mediated sexually dimorphic regulation of cytochrome P₄₅₀ 3A10/lithocholic acid 6β-hydroxylase”. Nucleic Acids Res. 26: 2173—2178. PMID 9547277.

[4] Russell, D.W. (2003). „The enzymes, regulation, and genetics of bile acid synthesis”. Annu. Rev. Biochem. 72: 137—174. PMID 12543708.

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