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PubMed	članci
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Linoleat 10R-lipoksigenaza
Linoleat 10R-lipoksigenaza
Identifikatori
EC broj	1.13.11.62
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Linoleat 10R-lipoksigenaza (EC 1.13.11.62, 10R-DOX, (10R)-dioksigenaza, 10R-dioksigenaza) je enzim sa sistematskim imenom linoleat:kiseonik (10R)-oksidoreduktaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

linoleat + O₂

\rightleftharpoons

(8E,10R,12Z)-10-hidroperoksi-8,12-oktadekadienoat

Ovaj enzim učestvuje u biosintezi oksilipina, koji utiče na sporulaciju, razviće i patogenost Aspergillus sp.

Reference

^ Garscha, U. & Oliw, E.H. (2009). „Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis of (10R)-dioxygenase with epoxyalcohol synthase activity”. J. Biol. Chem. 284: 13755—13765. PMID 19289462.
^ Jerneren, F., Garscha, U., Hoffmann, I., Hamberg, M. and Oliw, E.H. (2010). „Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus”. Biochim. Biophys. Acta. 1801: 503—507. PMID 20045744.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Linoleate+10R-lipoxygenase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Garscha, U. & Oliw, E.H. (2009). „Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis of (10R)-dioxygenase with epoxyalcohol synthase activity”. J. Biol. Chem. 284: 13755—13765. PMID 19289462.

[2] Jerneren, F., Garscha, U., Hoffmann, I., Hamberg, M. and Oliw, E.H. (2010). „Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus”. Biochim. Biophys. Acta. 1801: 503—507. PMID 20045744.

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