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Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Linalool 8-monooksigenaza
Linalool 8-monooksigenaza
Identifikatori
EC broj	1.14.13.151
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Linalool 8-monooksigenaza (EC 1.14.13.151, P-450lin, CYP111) je enzim sa sistematskim imenom linalol,NADH:kiseonik oksidoreduktaza (8-hidroksilacija).^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

linalool + 2 NADH + 2 H⁺ + 2 O₂

\rightleftharpoons

(6E)-8-oksolinalol + 2 NAD⁺ + 3H₂O (sveukupna reakcija)

(1a) linalol + NADH + H⁺ + O₂

\rightleftharpoons

(6E)-8-hidroksilinalol + NAD⁺ + H₂O

(1b) (6E)-8-hidroksilinalol + NADH + H⁺ + O₂

\rightleftharpoons

(6E)-8-oksolinalol + NAD⁺ + 2H₂O

Ovaj enzim je hem-tiolatni protein (P-450). Sekundarni elektronski donor je specifično [2Fe-2S] feredoksin iz iste bakterijske vrste.

Reference

^ Ullah, A.J., Murray, R.I., Bhattacharyya, P.K., Wagner, G.C. and Gunsalus, I.C. (1990). „Protein components of a cytochrome P-450 linalool 8-methyl hydroxylase”. J. Biol. Chem. 265: 1345—1351. PMID 2295633.
^ Ropp, J.D., Gunsalus, I.C. and Sligar, S.G. (1993). „Cloning and expression of a member of a new cytochrome P-450 family: cytochrome P-450lin (CYP111) from Pseudomonas incognita”. J. Bacteriol. 175: 6028—6037. PMID 8376348.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Linalool+8-monooxygenase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Ullah, A.J., Murray, R.I., Bhattacharyya, P.K., Wagner, G.C. and Gunsalus, I.C. (1990). „Protein components of a cytochrome P-450 linalool 8-methyl hydroxylase”. J. Biol. Chem. 265: 1345—1351. PMID 2295633.

[2] Ropp, J.D., Gunsalus, I.C. and Sligar, S.G. (1993). „Cloning and expression of a member of a new cytochrome P-450 family: cytochrome P-450lin (CYP111) from Pseudomonas incognita”. J. Bacteriol. 175: 6028—6037. PMID 8376348.

[1]

[2]