Legumain

Legumain
Identifikatori
EC broj3.4.22.34
CAS broj149371-18-6
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Legumain (EC 3.4.22.34, asparaginska endopeptidaza, citvak, proteinaza B, hemoglobinaza, PRSC1 genski produkt (Homo sapiens), vicilinska peptidohidrolaza, endopeptidaza pasulja, vicilinska peptidohidrolaza) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Hidroliza proteina i malih molekulskih supstrata na -Asn-Xaa- vezama

Ovaj enzim je prisutan u mahunama metilja Schistosoma mansoni, i u lizozomima sisara.

Reference

  1. ^ Hara-Nishimura, I. (1998). „Asparaginyl endopeptidase”. Ур.: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. Handbook of Proteolytic Enzymes. London: Academic Press. стр. 746—749. 
  2. ^ Dalton, J.P. & Brindley, P.J. (1998). „Schistosome legumain”. Ур.: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. Handbook of Proteolytic Enzymes. London: Academic Press. стр. 749—754. 
  3. ^ Chen, J.-M., Rawlings, N.D., Stevens, R.A.E. and Barrett, A.J. (1998). „Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases”. FEBS Lett. 441: 361—365. PMID 9891971. 

Литература

  • Dalton, J.P. & Brindley, P.J. (1998). „Schistosome legumain”. Ур.: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. Handbook of Proteolytic Enzymes. London: Academic Press. стр. 749—754. 
  • Hara-Nishimura, I. (1998). „Asparaginyl endopeptidase”. Ур.: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. Handbook of Proteolytic Enzymes. London: Academic Press. стр. 746—749. 

Spoljašnje veze

  • Legumain на US National Library of Medicine Medical Subject Headings (MeSH)