PROFILPELAJAR.COM

Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Katepsin V
Katepsin V
Identifikatori
EC broj	3.4.22.43
CAS broj	223670-00-6
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Katepsin V (EC 3.4.22.43, katepsin L2, katepsin U) je enzim.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Ovaj rekombinantni enzim hidrolizuje proteine (serumski albumin, kolagen) i sintetičke supstrate (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec)

Katepsin V je ljudska lizozomalna cisteinska endopeptidaza iz familije C1 (papainske familije) koja je maksimalno aktivna na pH 5m7 i nestabilna na neutralnom pH.

Reference

^ Brömme, D., Li, Z., Barnes, M. and Mehler, E. (1999). „Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization”. Biochemistry. 38: 2377—2385. PMID 10029531.
^ Adachi, W., Kawamoto, S., Ohno, I., Nishida, K., Kinoshita, S., Matsubara, K. and Okubo, K. (1998). „Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium”. Invest. Ophthalmol. Vis. Sci. 39: 1789—1796. PMID 9727401.
^ Santamaría, I., Velasco, G., Cazorla, M., Fueyo, A., Campo, E. and López-Otín, C. (1998). „Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas”. Cancer Res. 58: 1624—1630. PMID 9563472.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Cathepsin+V на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Brömme, D., Li, Z., Barnes, M. and Mehler, E. (1999). „Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization”. Biochemistry. 38: 2377—2385. PMID 10029531.

[2] Adachi, W., Kawamoto, S., Ohno, I., Nishida, K., Kinoshita, S., Matsubara, K. and Okubo, K. (1998). „Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium”. Invest. Ophthalmol. Vis. Sci. 39: 1789—1796. PMID 9727401.

[3] Santamaría, I., Velasco, G., Cazorla, M., Fueyo, A., Campo, E. and López-Otín, C. (1998). „Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas”. Cancer Res. 58: 1624—1630. PMID 9563472.

[1]

[2]

[3]