Karbonil reduktaza (NADPH)

Karbonil reduktaza (NADPH) (EC 1.1.1.184, aldehid reduktaza 1, prostaglandin 9-ketoreduktaza, ksenobiotik keton reduktaza, NADPH-zavisna karbonilna reduktaza, ALR3, karbonilna reduktaza, nespecifična NADPH-zavisna karbonilna reduktaza, karbonilna reduktaza (NADPH2)) je enzim sa sistematskim imenom sekundarni-alkohol:NADP⁺ oksidoreduktaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

R-CHOH-R' + NADP⁺

\rightleftharpoons

R-CO-R' + NADPH + H⁺

Ovaj enzim deluje na širok opseg karbonilnih jedinjenja, uključujući hinone, aromatične aldehide, ketoaldehide, daunorubicin i prostaglandine E and F, redukujući ih do korespondirajućih alkohola. On je B-specifičan u pogledu NADPH (cf. EC 1.1.1.2, alkohol dehidrogenaza (NADP⁺)).

Reference

^ Ahmed, N.K., Felsted, R.L. and Bachur, N.R. (1978). „Heterogeneity of anthracycline antibiotic carbonyl reductases in mammalian livers”. Biochem. Pharmacol. 27: 2713—2719. PMID 31888.
^ Lin, Y.M. & Jarabak, J. (1978). „Isolation of two proteins with 9-ketoprostaglandin reductase and NADP-linked 15-hydroxyprostaglandin dehydrogenase activities and studies on their inhibition”. Biochem. Biophys. Res. Commun. 81: 1227—1234. PMID 666816.
^ Wermuth, B. (1981). „Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase”. J. Biol. Chem. 256: 1206—1213. PMID 7005231.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Carbonyl+reductase+(NADPH) на US National Library of Medicine Medical Subject Headings (MeSH)

п р у Enzimi
Teme	Aktivno mesto Alosterna regulacija Mesto vezivanja Katalitički perfektan enzim Koenzim Kofaktor Kooperativnost EC broj Enzimska kataliza Inhibicija enzima Enzimska kinetika Lajnviver—Berkov dijagram Mihaelis—Mentenina kinetika Spisak enzima
Tipovi	EC1 Oksidoreduktaze /spisak EC2 Transferaze /spisak EC3 Hidrolaze /spisak EC4 Lijaze /spisak EC5 Izomeraze /spisak EC6 Ligaze /spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

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